Pretransplant Psoas Muscle Cross-Sectional Area and Postkidney Transplant Outcomes.
Pretransplant Psoas Muscle Cross-Sectional Area and Postkidney Transplant Outcomes.
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移植前腰肌横截面积和肾移植后结果。
DOI：
10.1016/j.transproceed.2022.05.035
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发表时间：
2022-09
影响因子：
0.9
通讯作者：
Gupta A
中科院分区：
文献类型：
--
作者：
Norris T;Montgomery R;Cibrik D;Reintjes M;Chakraborty S;Fishback S;Gupta A
肌肉减少症与终末期肾病 (ESKD) 的不良后果相关。我们评估了移植前肌少症是否影响肾移植（KT）受者的移植后结果。在这项针对成年 ESKD 患者的单中心回顾性研究中，我们使用针对年龄、性别和种族进行调整的 Cox 比例风险模型，分析了 KT 前腰肌横截面积与估计肾小球滤过率 (eGFR) 下降、移植物丢失、再住院和死亡率等关键移植后结果之间的关联。 573 名 KT 接受者在评估 KT 资格期间进行了 KT 前腹部和骨盆 CT 扫描。其中，465 名 KT 接受者接受了单纯肾脏移植，71 名接受了同时肝肾移植 (SLK)，37 名接受了同时胰肾移植 (SPK)。患者年龄为 49±13 岁，其中 16% 为黑人，60% 为男性。对于单纯肾移植受者来说，较高的腰肌横截面积与较短的住院时间相关（β系数-0.003，95% CI -0.005，-0.0007）。相反，KT 前腰肌横截面积并不能预测 eGFR 下降、移植物丢失、死亡率或早期再住院。对于 SLK 接受者，腰肌横截面积不能预测任何先验结果。对于 SPK 接受者，移植前腰肌横截面积越大，预示住院时间越长（β 系数 0.03，95% CI 0.01，0.05）。腰肌横截面积与其他评估结果之间没有关联。移植前腰肌横截面积不能预测移植后 eGFR 下降、移植物丢失、再住院或单纯肾脏移植、SPK 或 SLK 移植的死亡率。
Sarcopenia is associated with adverse outcomes in end stage kidney disease (ESKD). We evaluated if pre-transplant sarcopenia affects post-transplant outcomes in kidney transplant (KT) recipients. In this single center retrospective study of adult ESKD patients, we analyzed the association between pre-KT psoas muscle cross-sectional area and critical post-transplant outcomes of decline in estimated glomerular filtration rate (eGFR), graft loss, rehospitalization, and mortality using Cox proportional hazard model adjusted for age, sex, and race. Pre-KT abdomen and pelvis CT scans performed during evaluation for KT eligibility were available for 573 KT recipients. Of these, 465 KT recipients received kidney alone transplant, 71 received simultaneous liver kidney transplant (SLK), and 37 received simultaneous pancreas kidney transplant (SPK). Patients were 49±13 years old, 16% Black, and 60% men. For kidney alone transplant recipients, a higher psoas muscle cross sectional area was associated with a shorter length of hospitalization (β coefficient −0.003, 95% CI −0.005, −0.0007). Conversely, pre-KT psoas muscle cross sectional area did not predict decline in eGFR, graft loss, mortality, or early rehospitalization. For SLK recipients, psoas muscle cross sectional area did not predict any of the a priori outcomes. For SPK recipients, higher pre-transplant psoas muscle cross sectional area predicted a longer length of hospitalization (β coefficient 0.03, 95% CI 0.01, 0.05). There was no association between psoas muscle cross sectional area and other outcomes assessed. Pre-transplant psoas muscle cross sectional area is not predictive of post-transplant decline in eGFR, graft loss, rehospitalization or mortality in kidney alone, SPK, or SLK transplants.
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影响因子：
3
作者：
Hanna, Ramy M.;Ghobry, Lena;Kalantar-Zadeh, Kamyar
通讯作者：
Kalantar-Zadeh, Kamyar
DOI：
10.1016/j.jamcollsurg.2010.03.039
发表时间：
2010-08
影响因子：
5.2
作者：
Englesbe, Michael J.;Patel, Shaun P.;He, Kevin;Lynch, Raymond J.;Schaubel, Douglas E.;Harbaugh, Calista;Holcombe, Sven A.;Wang, Stewart C.;Segev, Dorry L.;Sonnenday, Christopher J.
通讯作者：
Sonnenday, Christopher J.
DOI：
10.1016/j.clinre.2021.101692
发表时间：
2021-06-09
影响因子：
2.7
作者：
Mazzola, Alessandra;Brustia, Raffaele;Conti, Filomena
通讯作者：
Conti, Filomena
影响因子：
4.6
作者：
Fitzpatrick JA;Basty N;Cule M;Liu Y;Bell JD;Thomas EL;Whitcher B
通讯作者：
Whitcher B
影响因子：
4.4
作者：
Haak, Daniel;Page, Charles-E.;Deserno, Thomas M.
通讯作者：
Deserno, Thomas M.