The Animal Models of Dementia and Alzheimer's Disease for Pre-Clinical Testing and Clinical Translation
The Animal Models of Dementia and Alzheimer's Disease for Pre-Clinical Testing and Clinical Translation
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DOI：
10.2174/156720512803569055
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发表时间：
2012-11-01
影响因子：
2.1
通讯作者：
Masters, Colin L.
中科院分区：
文献类型：
--
作者：
Anand, Akshay;Banik, Avijit;Masters, Colin L.
痴呆是一种临床综合征，伴有异常程度的记忆丧失以及回忆过去事件的能力受损，通常以阿尔茨海默病为特征。治疗痴呆的各种策略需要在合适的动物模型中对新型化合物进行验证，以测试其安全性和有效性。这些可能包括源自合成化学的新型抗遗忘药物或源自传统草药的药物。已经采用了多种方法来创建可靠的动物模型，从啮齿动物到非人灵长类动物，在这些模型中，动物受到预先确定的损伤或在怀疑影响学习功能的大脑特定区域进行基因敲除。在这篇综述中，讨论了阿尔茨海默病的各种动物模型以及抗痴呆药物开发中的治疗策略，并试图对该领域的最新进展提供全面的报告。
Dementia is a clinical syndrome with abnormal degree of memory loss and impaired ability to recall events from the past often characterized by Alzheimer's disease. The various strategies to treat dementia need validation of novel compounds in suitable animal models for testing their safety and efficacy. These may include novel anti-amnesic drugs derived from synthetic chemistry or those derived from traditional herbal sources. Multiple approaches have been adopted to create reliable animal models ranging from rodents to non-human primates, where the animals are exposed to a predetermined injury or causing genetic ablation across specific regions of brain suspected to affect learning functions. In this review various animal models for Alzheimer's disease and treatment strategies in development of anti dementia drugs are discussed and an attempt has been made to provide a comprehensive report of the latest developments in the field.