Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract
Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract
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DOI：
10.1016/j.jep.2007.11.032
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发表时间：
2008-02-28
影响因子：
5.4
通讯作者：
Kempradub, Niwat
中科院分区：
文献类型：
--
作者：
Chittrakarn, Somsmorn;Sawangjaroen, Kitja;Kempradub, Niwat
Kratom （Mitragyna speciosa Korth.）是泰国的一种本土植物，传统上用于民间医学，尽管据称它会导致成瘾。它被用来治疗腹泻，然而，没有科学证据支持它的使用。本研究旨在探讨苦参叶甲醇提取物对大鼠胃肠道的影响。50、100、200和400 mg/kg （p.o）蓖麻提取物对大鼠蓖麻油致腹泻具有剂量依赖性保护作用，并能抑制肠道运输。止泻作用不受纳洛酮的拮抗。当给药1天时，苦参提取物对肠道运输的抑制作用与对照组有显著差异。对于15天和30天的长期治疗，苦参提取物并没有减少肠道运输时间，这表明适应已经发生。给药剂量为200和400 mg/kg、吗啡剂量为3 mg/kg （1 / p）的苦参提取物30 d后，小鼠体重增加幅度明显低于对照组和较低剂量（50和100 mg/kg）的苦参提取物。但对血浆胆囊收缩素水平无影响。结果表明，甲醇苦参提取物对大鼠胃肠道具有止泻作用。这种作用除了作用于阿片受体外，还可能通过其他途径发生。高剂量苦参提取物对小鼠体重的减少作用与吗啡相似。2007爱思唯尔爱尔兰有限公司版权所有。
Kratom (Mitragyna speciosa Korth.) is an indigenous plant of Thailand used traditionally in folk medicine although it is claimed to cause addiction. It is used to treat diarrhea, however, there is no scientific evidence to support the use. The aim of this study is to investigate the effect of methanolic extract of kratom leaves on the rat gastrointestinal tract. Kratom extract at 50, 100, 200 and 400 mg/kg (p.o.) caused a dose dependent protection against castor oil-induced diarrhea in rats and also inhibited intestinal transit. The antidiarrheal effect was not antagonized by naloxzone. The inhibition of intestinal transit by kratom extract was significantly different from the control when treated with a single dose for 1 day. For longer-term treatments of 15 and 30 days, kratom extract did not decrease the intestinal transit time indicating that adaptation had occurred. Kratom extract at a dose level of 200 and 400 mg/kg for 30 days and morphine at 3 mg/kg (i.p.) caused a decrease in the increment of body weight that was significantly different from the control and kratom extract at lower doses (50 and 100 mg/kg). However it had no effect on the level of plasma cholecystokinin. The results suggested that methanolic kratom extract exhibited its antidiarrheal effect on rat gastrointestinal tract. The effects may occur via pathways in addition to the action on opioid receptors. High does of kratom extract decreased the increment of body weight similar to the effect of morphine. (c) 2007 Elsevier Ireland Ltd. All rights reserved.