New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity
New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity
复制标题
野木瓜果实中的新正齐墩果烷三萜类化合物具有潜在的抗炎活性
DOI：
10.1080/14786419.2018.1540478
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发表时间：
2020-04-02
影响因子：
2.2
通讯作者：
Meng, Dali
中科院分区：
文献类型：
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作者：
Li, Jiaheng;Du, Kaicheng;Meng, Dali
从短蕊野木瓜果实中分离得到6个正三萜和去甲齐墩果烷型三萜，其中包括两个新化合物：短蕊野木瓜苷B10（1）和短蕊野木瓜苷C1（2）。化合物1-3显示出对脂多糖（LPS）诱导的RAW 264.7巨噬细胞中一氧化氮产生的抑制活性，其IC 50值分别为27.04、26.22和21.41 μ M，均强于吲哚美辛。本研究不仅发现了一种新的去甲齐墩果烷型三萜化合物，而且证实了三种去甲齐墩果烷型三萜化合物作为NO生成抑制剂的抗炎活性。
The continuing studies on the fruits of Stauntonia brachyanthera led to the isolations of 6 normal and nor-oleanane triterpenoids, including two new compounds, brachyantheoraside B10 (1) and brachyantheraside C1 (2). Compounds 1-3 showed inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 27.04, 26.22, and 21.41 mu M, respectively, which were all stronger than that of indomethacin. The study not only revealed a new type of nor-oleanane triterpenoids, but also confirmed the anti-inflammation abilities of three type nor-oleanane triterpenoids as the inhibitors of NO production.