Ovarian toxicity and metabolism of 4-vinylcyclohexene and analogues in B6C3F1 mice: structure-activity study of 4-vinylcyclohexene and analogues.
Ovarian toxicity and metabolism of 4-vinylcyclohexene and analogues in B6C3F1 mice: structure-activity study of 4-vinylcyclohexene and analogues.
复制标题
4-乙烯基环己烯及其类似物在 B6C3F1 小鼠中的卵巢毒性和代谢：4-乙烯基环己烯及其类似物的结构活性研究。
DOI：
10.1007/978-1-4757-9480-9_46
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发表时间：
1996
影响因子：
--
通讯作者：
Sipes,IG
中科院分区：
文献类型：
--
作者：
Doerr,JK;Sipes,IG
工业化学品4-乙烯基环己烯(VCH)是一种对小鼠的卵巢毒物。服用VCH 30天会导致卵巢卵泡耗尽，包括原始卵泡(Smith等人，1990a；Hooser等人，1994年)。破坏这些未分裂的卵泡会产生不可逆转的反应，导致卵巢早衰(Hooser等人，1994)。由于VCH治疗直到卵巢衰竭的发生才观察到对周期、激素水平和生育能力的影响(Hooser等人，1994；Grize等人，1994)，卵巢毒性的早期预警迹象并不明显。此外，卵巢衰竭被认为与卵巢肿瘤的发展有关(Hooser等人，1994)。在长期服用VCH后，观察到罕见卵巢肿瘤的发生率增加，包括混合良性肿瘤、颗粒细胞瘤和颗粒细胞癌(NTP，1986)。
The industrial chemical, 4-vinylcyclohexene (VCH), is an ovarian toxicant in mice. Administration of VCH for thirty days results in depletion of ovarian follicles, including primordial follicles (Smith et al., 1990a; Hooser et al., 1994). Destruction of these non-dividing follicles produces an irreversible response that leads to the development of premature ovarian failure (Hooser et al., 1994). Since no effect in cyclicity, hormonal levels, and fertility are observed with VCH treatment until the development of ovarian failure (Hooser et al., 1994; Grizzle et al., 1994), early warning signs of ovarian toxicity are not apparent. In addition, ovarian failure is believed to be associated with the development of ovarian neoplasms (Hooser et al., 1994). An increased incidence in the occurrence of uncommon ovarian neoplasms; including mixed benign tumors, granulosa cell tumors, and granulosa cell carcinomas, is observed following chronic administration of VCH (NTP, 1986).