Leukocyte and lymphocyte cyclic AMP responses in atopic eczema.
Leukocyte and lymphocyte cyclic AMP responses in atopic eczema.
复制标题
特应性湿疹中白细胞和淋巴细胞环磷酸腺苷反应。
DOI：
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发表时间：
1977
影响因子：
6.5
通讯作者：
A. Eisen
中科院分区：
文献类型：
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作者：
C. Parker;S. Kennedy;A. Eisen
将患有轻度和重度特应性湿疹的受试者的淋巴细胞与正常对照受试者的淋巴细胞对各种刺激剂的 cAMP（3'；5'-环单磷酸腺苷）反应进行比较。严重湿疹组中的个体未受刺激的淋巴细胞 cAMP 水平和对 0.5 mM 茶碱、0.5 mM 茶碱 + 1 µmM 肾上腺素、10 mM 异丙肾上腺素、1 mM 异丙肾上腺素、10 mM 沙丁胺醇和 3 µM PGE1 的绝对 cAMP 反应显着降低。患有轻度湿疹的个体对 0.5 mM 茶碱的反应减弱。严重湿疹组的许多反应也与 5 名患有严重牛皮癣的受试者组不同。还检查了混合白细胞 cAMP 对 10 mM 异丙肾上腺素的反应，发现湿疹个体的混合白细胞 cAMP 反应减弱。
Lymphocytes from subjects with mild and severe atopic eczema were compared with normal control subjects in regard to their cAMP (3';5'-cyclic adenosine monophosphate) responses to a variety of stimulatory agents. Individuals in the severe eczema group were shown to have a significant diminution in their unstimulated lymphocyte cAMP levels and absolute cAMP responses to 0.5 mM theophylline, 0.5 mM theophyline + 1 micronM epinephrine, 10 mM isoproternol, 1 mM isoproterenol, 10 mM salbutamol, and 3 micron M PGE1. Individuals with mild eczema had a reduced response to 0.5 mM theophylline. The severe eczema groups also differed in a number of these responses from a group of 5 subjects with severe psoriasis. Mixed leukocyte cAMP responses to 10 mM isoproterenol also were examined and found to be diminished in individuals with eczema.