Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection
Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection
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DOI：
10.1016/j.cell.2006.08.043
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发表时间：
2006-10-20
期刊：
影响因子：
64.5
通讯作者：
Gordon, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Rawls, John F.;Mahowald, Michael A.;Gordon, Jeffrey I.
斑马鱼和小鼠的肠道微生物群共有六个细菌部门，尽管这些部门中的特定细菌不同。为了测试宿主肠道栖息地的特定因素如何塑造微生物群落结构，我们将这些微生物群相互移植到无菌斑马鱼和小鼠受体中。结果表明，社区是以可预测的方式聚集的。移植的群落在存在的谱系方面类似于其起源的群落，但是谱系的相对丰度改变为类似于受体宿主的正常肠道微生物群落组成。因此，斑马鱼和小鼠之间的群落结构差异部分源于每个宿主肠道栖息地内施加的不同选择压力。尽管如此，脊椎动物对肠道微生物定植的反应是古老的：功能基因组研究揭示了共同的宿主对其组成不同的微生物群落和引起保守反应的不同微生物物种的反应。
The gut microbiotas of zebrafish and mice share six bacterial divisions, although the specific bacteria within these divisions differ. To test how factors specific to host gut habitat shape microbial community structure, we performed reciprocal transplantations of these microbiotas into germ-free zebrafish and mouse recipients. The results reveal that communities are assembled in predictable ways. The transplanted community resembles its community of origin in terms of the lineages present, but the relative abundance of the lineages changes to resemble the normal gut microbial community composition of the recipient host. Thus, differences in community structure between zebrafish and mice arise in part from distinct selective pressures imposed within the gut habitat of each host. Nonetheless, vertebrate responses to microbial colonization of the gut are ancient: Functional genomic studies disclosed shared host responses to their compositionally distinct microbial communities and distinct microbial species that elicit conserved responses.