The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
复制标题
DOI：
10.1016/j.jneuroim.2013.04.009
复制
发表时间：
2013-07-15
影响因子：
3.3
通讯作者：
Garlanda, Cecilia
中科院分区：
文献类型：
--
作者：
Locatelli, Marco;Ferrero, Stefano;Garlanda, Cecilia
Inflammation is a component of glioma microenvironment PTX3 is a component of the humoral arm of innate immunity and a candidate marker of inflammation.In the present study we assessed the expression of PTX3 in gliomas by immunohistochemistry. PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity. In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy. (C) 2013 Elsevier B.V. All rights reserved.
