Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.
Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.
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DOI：
10.1101/gad.244772.114
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发表时间：
2014-07-15
影响因子：
10.5
通讯作者：
Fuchs E
中科院分区：
文献类型：
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作者：
Lien WH;Fuchs E
在哺乳动物中，Wnt/β-catenin信号在干细胞和癌症中具有突出的特征，但如何以及出于什么目的一直存在争议。在这篇综述中，Lien和Fuchs总结了Wnt/β-catenin信号传导及其下游转录调节因子在正常和恶性干细胞中的当前知识，特别强调胚胎干细胞，毛囊干细胞和肠上皮干细胞。在哺乳动物中，Wnt/β-catenin信号在干细胞和癌症中具有突出的特征，但如何以及出于什么目的一直存在争议。本文就Wnt/β-catenin信号通路及其下游转录调控因子在正常和恶性干细胞中的作用进行综述。我们主要集中在这三种类型的干细胞-胚胎干细胞，毛囊干细胞，肠上皮干细胞-其中Wnt/β-catenin的作用已被广泛研究的审查。使用这些模型，我们揭示了围绕Wnt信号传导的许多有争议的问题已经通过解剖其下游回路和效应器的多样性得到解决，通常导致Wnt/β-连环蛋白介导的调节的相反结果以及植根于阶段和背景依赖性效应的差异。
In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but how and for what purposes have been matters of debate. In this review, Lien and Fuchs summarize the current knowledge of Wnt/β-catenin signaling and its downstream transcriptional regulators in normal and malignant stem cells, with particular emphasis on embryonic stem cells, hair follicle stem cells, and intestinal epithelial stem cells. In mammals, Wnt/β-catenin signaling features prominently in stem cells and cancers, but how and for what purposes have been matters of much debate. In this review, we summarize our current knowledge of Wnt/β-catenin signaling and its downstream transcriptional regulators in normal and malignant stem cells. We centered this review largely on three types of stem cells—embryonic stem cells, hair follicle stem cells, and intestinal epithelial stem cells—in which the roles of Wnt/β-catenin have been extensively studied. Using these models, we unravel how many controversial issues surrounding Wnt signaling have been resolved by dissecting the diversity of its downstream circuitry and effectors, often leading to opposite outcomes of Wnt/β-catenin-mediated regulation and differences rooted in stage- and context-dependent effects.
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