Spatiotemporal regulation of the cough motor pattern.
Spatiotemporal regulation of the cough motor pattern.
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DOI：
10.1186/1745-9974-5-12
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发表时间：
2009-12-22
期刊：
影响因子：
--
通讯作者：
Bolser DC
中科院分区：
文献类型：
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作者：
Wang C;Saha S;Rose MJ;Davenport PW;Bolser DC
本研究的目的是确定咳嗽运动模式的时空决定因素。我们推测咳嗽运动模式的空间和时间特征将被单独调节。记录麻醉猫的腹部肌肉（ABD、腹直肌或腹横肌）和胸骨旁肌肉（PS）的肌电图（EMG）。反复咳嗽是由胸内气管腔的机械刺激引起的。咳嗽吸气 (CTI) 和呼气 (CTE) 持续时间通过 PS EMG 获得。 ABD EMG 爆发仅限于 CTE 的早期部分，随后是不同持续时间的静止期。因此，CTE 分为两个部分，CTE1 定义为 ABD EMG 突发的持续时间，CTE2 定义为 ABD EMG 中很少或没有 EMG 活动的时间段。总咳嗽周期持续时间（CTTOT）与CTE2强相关（r2>0.8），与CTI弱相关（r2<0.3），与CTE1不相关（r2<0.2）。 CTI与CTE1或CTE2之间没有显着关系。咳嗽期间吸气和呼气运动驱动的幅度彼此之间仅有弱相关（r2<0.36），并且与咳嗽任何阶段的持续时间均不相关。结果支持：a) CTI 和 CTE 的单独调节，b) CTE 的两个不同子阶段（CTE1 和 CTE2），c) CTE2 的持续时间是 CTTOT 的主要决定因素，以及 d) 咳嗽运动模式的幅度和时间特征的单独调节。
The purpose of this study was to identify the spatiotemporal determinants of the cough motor pattern. We speculated that the spatial and temporal characteristics of the cough motor pattern would be regulated separately. Electromyograms (EMG) of abdominal muscles (ABD, rectus abdominis or transversus abdominis), and parasternal muscles (PS) were recorded in anesthetized cats. Repetitive coughing was produced by mechanical stimulation of the lumen of the intrathoracic trachea. Cough inspiratory (CTI) and expiratory (CTE) durations were obtained from the PS EMG. The ABD EMG burst was confined to the early part of CTE and was followed by a quiescent period of varying duration. As such, CTE was divided into two segments with CTE1 defined as the duration of the ABD EMG burst and CTE2 defined as the period of little or no EMG activity in the ABD EMG. Total cough cycle duration (CTTOT) was strongly correlated with CTE2 (r2>0.8), weakly correlated with CTI (r2<0.3), and not correlated with CTE1 (r2<0.2). There was no significant relationship between CTI and CTE1 or CTE2. The magnitudes of inspiratory and expiratory motor drive during cough were only weakly correlated with each other (r2<0.36) and were not correlated with the duration of any phase of cough. The results support: a) separate regulation of CTI and CTE, b) two distinct subphases of CTE (CTE1 and CTE2), c) the duration of CTE2 is a primary determinant of CTTOT, and d) separate regulation of the magnitude and temporal features of the cough motor pattern.