Cholangiocarcinoma associated with biliary cirrhosis due to congenital biliary atresia.
Cholangiocarcinoma associated with biliary cirrhosis due to congenital biliary atresia.
复制标题
由于先天性胆道闭锁导致胆管癌与胆汁性肝硬化相关。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
E. Beatty
中科院分区：
文献类型：
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作者：
P. Kulkarni;E. Beatty
一个11岁的女孩由于先天性胆道闭锁发展成胆管细胞癌并伴有胆汁性肝硬化。在三个月大时进行剖腹探查术及手术胆道造影证实为肝外胆道闭锁。6个月大时的肝活检标本显示胆汁性肝硬化。随后的临床过程的特点是持续中度黄疸，贫血，营养不良，佝偻病，病理性骨折，和复发性胃肠道出血。在她去世前一周，在剖腹探查术中确定了肝胆管细胞癌伴晚期胆汁性肝硬化的存在。我们在这里讨论的胆汁性肝硬化和肝癌的发病机制，有可能是两者之间的关系，在儿童人口。
An 11-year-old girl developed cholangiocellular carcinoma in association with biliary cirrhosis due to congenital biliary atresia. An exploratory laparotomy and an operative cholangiogram at 3 months of age had confirmed the diagnosis of extrahepatic biliary atresia. A liver biopsy specimen taken at 6 months of age showed biliary cirrhosis. The subsequent clinical course was characterized by persistent moderate jaundice, anemia, malnutrition, rickets, pathologic fractures, and recurrent gastrointestinal bleeding. The presence of cholangiocellular carcinoma of the liver with advanced biliary cirrhosis was established at an exploratory laparotomy a week before her death. We discuss here the pathogenesis of biliary cirrhosis and carcinoma of the liver; there may be a relation between the two in the childhood population.