Lifetime alcohol consumption and severity in alcohol dependence syndrome.
Lifetime alcohol consumption and severity in alcohol dependence syndrome.
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DOI：
10.4103/ipj.ipj_26_17
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发表时间：
2017-01-01
影响因子：
--
通讯作者：
Singh, Ranveer
中科院分区：
文献类型：
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作者：
Dwivedi, Arun Kumar;Chatterjee, Kaushik;Singh, Ranveer
简介：酒精依赖综合症是全球主要的公共卫生问题，导致严重的发病率和死亡率。饮酒总量与肝脏疾病、胰腺炎和其他与酒精相关的医疗后果有关。然而，尚未对这与依赖性严重程度的关系进行研究；尽管众所周知，酒精会导致神经元损伤，从而增强依赖性。因此，有必要研究饮酒量与酒精依赖严重程度之间的关系。 材料和方法：对三级医院综合医院精神科的总共 165 例连续酒精依赖综合征病例进行了研究。成瘾严重程度指数（ASI）用于评估酒精依赖的严重程度，终身酒精消耗量（LTAC）通过仔细询问病史来评估。计算 ASI 和 LTAC 之间的相关系数。采用t检验分析组间差异。结果：ASI和LTAC之间存在显着相关性（r = 0.162，P = 0.032），这在无医疗并发症的亚组中非常显着（r = 0.250，P = 0.003）。医疗并发症亚组中的类似相关性并不显着。结论：终生饮酒量与酒精依赖的严重程度相关，尤其是那些没有医疗并发症的人（即那些有行为和社会后果以及受伤的人）。
INTRODUCTION: Alcohol dependence syndrome is a major public health issue globally and is responsible for significant morbidity and mortality. The total dose of alcohol consumed has been linked to liver diseases, pancreatitis, and other alcohol-related medical consequences. However, this has not been studied in relation to severity of dependence; although it is well known that alcohol causes neuronal damage, which in turn potentiates dependence. Thus, there is a need to study the relationship between the amount of alcohol consumed and severity of dependence.MATERIALS AND METHODS: A total of 165 consecutive cases of alcohol dependence syndrome were studied in a General Hospital Psychiatry Unit at a tertiary care hospital. Addiction Severity Index (ASI) was used to evaluate the severity of alcohol dependence, and Life Time Alcohol Consumption (LTAC) was evaluated by taking careful history. Correlation coefficients were calculated between ASI and LTAC. Group differences were analyzed using t-test.RESULTS: There was a significant correlation between ASI and LTAC (r = 0.162, P = 0.032), which was highly significant in the subgroup without medical complications (r = 0.250, P = 0.003). A similar correlation in the medical complications subgroup was not significant.CONCLUSIONS: Lifetime alcohol consumption co-related with the severity of alcohol dependence, particularly in those presenting without medical complications (i.e., those with behavioral and social consequences, and injuries).