Blood glutamine synthetase signaling in alcohol use disorder and racial disparity.
Blood glutamine synthetase signaling in alcohol use disorder and racial disparity.
复制标题
DOI：
10.1038/s41398-022-01837-w
复制
发表时间：
2022-02-22
影响因子：
6.8
通讯作者：
Nam HW
中科院分区：
文献类型：
--
作者：
Nahar L;Kaufman SE;Davis PG;Saunders SL;Disbrow EA;Patterson JC;Nam HW
As of 2018, 14.4 million adults ages 18 and older in the U.S had alcohol use disorder (AUD). However, only about 8% of adults who had AUD in the past year received treatment. Surveys have also shown racial disparities regarding AUD treatments. Thus, it is imperative to identify racial disparities in AUD patients, as it may indicate a specific underlying pathophysiology in an AUD subpopulation. To identify racial disparity in AUD, we enrolled 64 cohorts, including 26 AUD participants and 38 healthy controls, from Northwest Louisiana using community-based enrollment. Then, we used psychometric scales to assess alcohol drinking patterns and measured blood metabolites change using LC-MS/MS. Alcohol-related scales from the questionnaires did not differ between the Caucasian AUD participants and African-American AUD participants. From blood metabolomics analyses, we identified that 6 amino acids were significantly different by AUD status and or race. Interestingly, Caucasian AUD participants had a higher glutamate metabolism mediated by glutamine synthetase (GS). The correlation between blood glutamate/glutamine ratio and GS activity was only significant in the Caucasian AUD group whereas no changes were observed in African-American AUD group or controls. Taken together, our findings from this sample population demonstrate that blood GS is a potential biomarker associated with Caucasian AUD, which is an important step towards the application of a new pharmacological treatment for AUD.
登录
查看更多内容
影响因子：
7.4
作者：
Armenta, Jenny M.;Cortes, Diego F.;Pisciotta, John M.;Shuman, Joel L.;Blakeslee, Kenneth;Rasoloson, Dominique;Ogunbiyi, Oluwatosin;Sullivan, David J., Jr.;Shulaev, Vladimir
通讯作者：
Shulaev, Vladimir
DOI：
10.1097/00000374-200204000-00021
发表时间：
2002-04-01
影响因子：
3.2
作者：
Koob, GF;Mason, BJ;Siggins, GR
通讯作者：
Siggins, GR
影响因子：
3.4
作者：
Mann, Karl;Lemenager, Tagrid;Anton, Raymond F.
通讯作者：
Anton, Raymond F.
影响因子：
4.7
作者：
Hinton, David J.;Lee, Moonnoh R.;Choi, Doo-Sup
通讯作者：
Choi, Doo-Sup
影响因子：
--
作者：
Bush, K;Kivlahan, DR;Bradley, KA
通讯作者：
Bradley, KA