INVIVO MASS-SPECTROMETRIC DETERMINATION OF ORGANIC-COMPOUNDS IN BLOOD WITH A MEMBRANE PROBE
INVIVO MASS-SPECTROMETRIC DETERMINATION OF ORGANIC-COMPOUNDS IN BLOOD WITH A MEMBRANE PROBE
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DOI：
10.1021/ac00130a017
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发表时间：
1987-02-01
影响因子：
7.4
通讯作者：
DRYZGA, MD
中科院分区：
文献类型：
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作者：
BRODBELT, JS;COOKS, RG;DRYZGA, MD
一种改进的静脉膜探针，使用中空纤维硅管，用于体内质谱血液分析。血液（体外）中二氯甲烷、甲氧基氟醚和苯乙烯的检测限为1ppm或更低。响应时间为几分钟。大鼠吸入二氯甲烷或甲氧基氟醚是通过监测血液中的化合物来检测的。在体内监测二氯甲烷浓度，发现其呈指数下降（k = -0.15 min-1）。
An improved intravenous membrane probe, using hollow fiber silicon tubing, is used for in vivo mass spectrometric blood analysis. Detection limits in blood (in vitro) are 1 ppm or less for dichloromethane, methoxyflurane, and styrene. Response times are several minutes. Inhalation of dichloromethane or methoxyflurane by a rat is detected by monitoring the compound in the blood. The concentration of dichloromethane was monitored in vivo and found to fall exponentially (k = -0.15 min-1).