Blood pressure and renal function after kidney donation from hypertensive living donors
Blood pressure and renal function after kidney donation from hypertensive living donors
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DOI：
10.1097/01.tp.0000128168.97735.b3
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发表时间：
2004-07-27
期刊：
影响因子：
6.2
通讯作者：
Stegall, M
中科院分区：
文献类型：
--
作者：
Textor, SC;Taler, SJ;Stegall, M
背景：越来越多的终末期肾病患者增加了扩大活体肾脏供体库的需求。基于原发性高血压白色供体的低风险，我们的移植中心进行了一个结构化的计划，接受高血压供体，如果肾功能和尿蛋白正常。本研究报告的结果高血压捐助者一年后肾donate.Methods：我们研究了详细的测量血压（血压计，高血压治疗护士[RN]，动态血压监测[ABPM]），临床和肾脏的特点（碘酞酸肾小球滤过率[GFR]，尿蛋白，微量白蛋白）在148个活体肾供体肾切除术前和6至12个月后。24例为高血压（清醒ABPM>135/85 mm Hg和门诊/RN BP>140/90 mm Hg）。282天后，血压正常的供体清醒时ABPM压力没有变化（术前121 +/- 1/75 +/- 2 vs.术后120 +/- 1/ 5 +/- 1 mm Hg），而高血压供体的血压在非药物治疗和药物治疗后均下降（治疗前142 +/- 3/85 +/- 2至治疗后132 +/- 2/80 +/- 1 mmHg，P
Background: Rising numbers of patients reaching end-stage kidney disease intensify the demand for expansion of the living-kidney-donor pool. On the basis of low risk in white donors with essential hypertension, our transplant center undertook a structured program of accepting hypertensive donors if kidney function and urine protein were normal. This study reports outcomes of hypertensive donors I year after kidney donation.Methods: We studied detailed measurements of blood pressure (oscillometric, hypertensive therapy nurse [RN], and ambulatory blood pressure monitoring [ABPM]), clinical, and renal characteristics (iothalamate glomerular filtration rate [GFR], urine protein, and microalbumin) in 148 living kidney donors before and 6 to 12 months after nephrectomy. Twenty-four were hypertensive (awake ABPM>135/85 mm Hg and clinic/RN BP>140/90 mm Hg) before donation.Results: After 282 days, normotensive donors had no change in awake ABPM pressure (pre 121 +/- 1/75 +/- 2 vs. post 120 +/- 1/ 5 +/- 1 mm Hg), whereas BP in hypertensive donors fell with both nonpharmacologic and drug therapy (pre 142 +/- 3/85 +/- 2 to post 132 +/- 2/80 +/- 1 mmHg,P