Amphiphilic PEG-Based Ether-Anhydride Terpolymers: Synthesis, Characterization, and Micellization
Amphiphilic PEG-Based Ether-Anhydride Terpolymers: Synthesis, Characterization, and Micellization
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DOI：
10.1002/app.32724
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发表时间：
2010-12
影响因子：
3
通讯作者：
Aijun Zhao;Qi Zhou;T. Chen;J. Weng;Shaobing Zhou
中科院分区：
文献类型：
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作者：
Aijun Zhao;Qi Zhou;T. Chen;J. Weng;Shaobing Zhou
通过熔融缩合聚合合成了一系列由癸二酸、1,3-双（羧基苯氧基）丙烷和聚乙二醇（PEG）组成的两亲性聚（醚-酸酐）三元共聚物。所得三元共聚物通过 1 H 核磁共振光谱 ( 1 H-NMR)、傅里叶变换红外光谱、凝胶渗透色谱、X 射线衍射、偏光光学显微镜、差示扫描量热计和水接触角进行表征。通过自乳化沉淀法制备可生物降解的胶束。根据原子力显微镜和透射电子显微镜图像，这些胶束的形状是均匀的球形。动态光散射测量表明胶束的直径通常在 118-359 nm 范围内。结果表明，基于 PEG 的醚酐三元共聚物作为药物输送系统的纳米级载体可能具有巨大的潜力。 VC 2010 Wiley Journals, Inc. J Appl Polym Sci 118: 3576- 3585, 2010
A series of amphiphilic poly(ether-anhydrides) terpolymers composed of sebacic acid, 1,3-bis(carboxyphe- noxy) propane, and poly(ethylene glycol) (PEG) were synthe- sized via melt-condensation polymerization. The resultant terpolymers were characterized by 1 H-nuclear magnetic reso- nance spectroscopy ( 1 H-NMR), Fourier transform infrared spectroscopy, gel permeation chromatography, X-ray diffrac- tion, polarization optical microscope, differential scanning calorimeter, and water contact angle. Biodegradable micelles were prepared via a precipitation method through self-emul- sification. The shape of these micelles was uniform and spheric according to the atomic force microscopy and trans- mission electron microscopy images. The dynamic light scat- tering measurements indicated that the diameters of micelles were typically in the range of 118-359 nm. The results dis- played the PEG-based ether-anhydride terpolymers may be of great potential as nanoscaled carriers for drug delivery system. V C 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 3576- 3585, 2010