Assessment of Allergen Sensitization in a General Population-Based Survey (European Community Respiratory Health Survey I)
Assessment of Allergen Sensitization in a General Population-Based Survey (European Community Respiratory Health Survey I)
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DOI：
10.1016/j.annepidem.2010.05.012
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发表时间：
2010-11-01
影响因子：
5.6
通讯作者：
Burney, Peter
中科院分区：
文献类型：
--
作者：
Bousquet, Philippe-Jean;Castelli, Christel;Burney, Peter
目的：暴露在共同的环境中，ige介导的免疫反应是不同的，例如，在致敏的受试者中，有些人对一种过敏原（单致敏）有反应，而另一些人对多种过敏原（多致敏）有反应。然而，流行病学研究需要更好的表型表征。使用ECRHS I（欧洲共同体呼吸健康调查）期间收集的数据，比较了几种皮肤点刺试验和血清特异性IgE的评估，以确定单致敏和多致敏患者。方法：受试者参加ECRHS-I。CAP-System用于血清过敏原特异性lgE，过敏原包被法泽特用于点刺试验。用IgE测定了四种过敏原（鸡毛癣、猫、timothy grass和Cladosprium），并对九种过敏原（相同的过敏原加上橄榄花粉、桦树、Alternoria、顶叶草和豚草）进行了皮肤测试。根据国家的不同，还检测了一到两种当地过敏原。结果：11,355名受试者（34.0[27.9-40.1]岁，男性49.9%）的致敏率从32.3%（4次特异性IgE， 19.3%单一和13.0%多致敏）到41.8%（4次特异性IgE结合9次针刺试验，19.6%单一和22.2%多致敏）不等。4项特异性IgE与4项针刺试验的一致性较弱（加权K值为0.65[0.64-0.66]）。7次和9次针刺试验的一致性较高（加权K值0.99[0.98-1.00]）。局部变应原引起致敏率的微小变化，并将一些受试者从单一致敏重新分类为多致敏。结论：可选择皮肤试验或血清特异性IgE来鉴别过敏性、单致敏和多致敏受试者，而无需严格互换。中华流行病学杂志2010；20:797-803。(C) 2010爱思唯尔公司版权所有。
PURPOSE: Exposed to a common environment, the IgE-mediated immune response differs, for instance, among sensitized subjects, some of them reacting toward one allergen (monosensitized) whereas others are sensitized to a wide array of allergens (polysensitized). However, a better phenotypic characterization is needed for epidemiologic studies. Using the data collected during the ECRHS I (European Community Respiratory Health Survey), several assessments of skin prick tests and serum-specific IgE to identify mono- and polysensitized patients were compared.METHODS: Subjects took part in the ECRHS-I. The CAP-System was used for serum allergen-specific lgE, and allergen-coated Phazet was used for prick tests. Four allergens (Dermatophogoides pteronyssinus, cat, timothy grass, and Cladosprium) were measured using IgE and nine (the same ones plus olive pollen, birch, Alternoria, Parietaria, and ragweed) were skin tested. One to two local allergens were also tested, depending on countries.RESULTS: Prevalence of sensitization in 11,355 subjects (34.0 [27.9-40.1] years, 49.9% men) ranged from 32.3% (four specific IgE, 19.3% mono- and 13.0% polysensitized) to 41.8% (four specific IgE combined to nine prick tests, 19.6% mono- and 22.2% polysensitized). Concordance between four specific IgE and four prick tests was weak (weighted K 0.65 [0.64-0.66]). Concordance between seven and nine prick tests was high (weighted K 0.99 [0.98-1.00]). Local allergens induced small changes in the prevalence of sensitization, and reclassified some subjects from mono- to polysensitized.CONCLUSIONS: Skin tests or serum-specific IgE may be chosen to identify allergenic sensitivity, mono- and polysensitized subjects without being strictly interchangeable. Ann Epidemiol 2010;20:797-803. (C) 2010 Elsevier Inc. All rights reserved.