INVITRO CULTIVATION OF THE EXOERYTHROCYTIC STAGE OF PLASMODIUM-BERGHEI FROM SPOROZOITES
INVITRO CULTIVATION OF THE EXOERYTHROCYTIC STAGE OF PLASMODIUM-BERGHEI FROM SPOROZOITES
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DOI：
10.1126/science.7022652
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
BEAUDOIN, RL
中科院分区：
文献类型：
--
作者：
HOLLINGDALE, MR;LEEF, JL;BEAUDOIN, RL
当接种伯氏疟原虫的子孢子时，人胚肺细胞系W138支持红细胞外期的完整无性发育周期。培养的寄生虫伯氨喹敏感，并显示出类似于寄生虫在活的主机通过免疫荧光抗体试验，并对小鼠诱导红细胞感染，配子体产生子孢子按蚊。
When inoculated with sporozoites of P. berghei, the human embryonic lung cell line W138 supports the complete asexual developmental cycle of the exoerythrocytic stage. Cultured parasites were sensitive to primaquine, and shown to resemble parasites in living hosts by immunofluorescent antibody tests, and on subinoculation into mice induced a red blood cell infection, the gametocytes of which produced sporozoites in anopheline mosquitoes.