D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement
D-cycloserine and the facilitation of extinction of conditioned fear: Consequences for reinstatement
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DOI：
10.1037/0735-7044.118.3.505
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发表时间：
2004-06-01
影响因子：
1.9
通讯作者：
Cranney, J
中科院分区：
文献类型：
--
作者：
Ledgerwood, L;Richardson, R;Cranney, J
最近的几项研究报道，D-环丝氨酸（DCS），一个部分N-甲基-D-天冬氨酸激动剂，促进大鼠学习恐惧的消退。其他研究表明，非条件刺激（US）的表征可以在消失后恢复习得的恐惧。本研究检查了这种恢复效应是否发生在灭绝时给予DCS的Sprague-Dawley大鼠。结果表明，盐水处理的大鼠表现出恢复效果，但DCS处理的大鼠没有（实验1和2）。DCS处理的大鼠中缺乏恢复不是由于DCS对US或上下文处理的残留影响（实验3）。总之，这些结果（a）提出了关于DCS促进灭绝的机制的问题，（B）表明DCS可能具有实质性的实际益处。
Several recent studies have reported that D-Cycloserine (DCS), a partial N-methyl-D-aspartate agonist, facilitates extinction of learned fear in rats. Other studies have shown that representation of the unconditioned stimulus (US) can reinstate learned fear after extinction. This study examined whether this reinstatement effect occurs in Sprague-Dawley rats given DCS at the time of extinction. Results showed that saline-treated rats exhibited the reinstatement effect but DCS-treated rats did not (Experiments 1 and 2). This lack of reinstatement in DCS-treated rats was not due to residual effects of DCS on either US or context processing (Experiment 3). Overall, these results (a) raise questions about the mechanisms underlying DCS facilitation of extinction and (b) suggest that DCS might have substantial practical benefit.