MEDIATORS OF THE RELATIONSHIP BETWEEN NICOTINE REPLACEMENT THERAPY AND SMOKING ABSTINENCE AMONG PEOPLE LIVING WITH HIV/AIDS
MEDIATORS OF THE RELATIONSHIP BETWEEN NICOTINE REPLACEMENT THERAPY AND SMOKING ABSTINENCE AMONG PEOPLE LIVING WITH HIV/AIDS
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DOI：
10.1521/aeap.2009.21.3_supp.65
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发表时间：
2009-06-01
影响因子：
1.8
通讯作者：
Niaura, Raymond
中科院分区：
文献类型：
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作者：
Stanton, Cassandra A.;Lloyd-Richardson, Elizabeth E.;Niaura, Raymond
吸烟在艾滋病毒/艾滋病感染者中非常普遍，造成独特的健康风险。为这一人群量身定制的戒烟计划已经证明尼古丁替代疗法（NRT）改善了吸烟效果。目前的研究从一项随机临床试验中检测了6个月的戒烟率，该试验针对412名hiv阳性的成年吸烟者（51%的欧洲裔美国人，19%的非洲裔美国人，17%的西班牙裔美国人），并测试了社会心理变量，如自我效能感和决策平衡，是否介导了NRT和长期戒烟之间的关系。达到完全调节的标准，6个月戒烟率随着这些调节物的增加而显著提高，一旦考虑到自我效能感和决策平衡的变化，NRT与戒烟的关联不再显著。未能将非裔美国人自我效能感的提高转化为戒断率的提高，说明了参与者之间的种族/民族差异。具体的社会心理因素，如自我效能感，可能特别容易改变戒烟干预措施，在处理这些因素时，应更加认识到文化和社会背景因素如何影响艾滋病毒/艾滋病感染者的治疗反应。
Cigarette smoking is highly prevalent among people living with HIV/AIDS and poses unique health risks. Smoking cessation programs tailored to this population have documented improved smoking outcomes with nicotine replacement therapy (NRT). The current study examined 6-month abstinence rates from a randomized clinical trial targeting 412 HIV-positive adult current smokers (51% European American, 19% African American, and 17% Hispanic American) and tested whether psychosocial variables, such as self-efficacy and decisional balance, mediated the relationship between NRT and long-term abstinence. Meeting criteria for complete mediation, 6-month smoking abstinence rates improved significantly with increases in these mediators, and the association of NRT and smoking abstinence was no longer significant once changes in self-efficacy and decisional balance were taken into account. Failure to translate gains in self-efficacy among African Americans into improved abstinence rates accounted for racial/ethnic differences among participants. Specific psychosocial factors, such as self-efficacy, may be particularly amenable to change in cessation interventions and should be addressed with greater awareness of how cultural and social contextual factors impact treatment response among people living with HIV/AIDS.