Safety and acceptability of the research lumbar puncture
Safety and acceptability of the research lumbar puncture
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DOI：
10.1097/01.wad.0000194014.43575.fd
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发表时间：
2005-10-01
影响因子：
2.1
通讯作者：
Galasko, D
中科院分区：
文献类型：
--
作者：
Peskind, ER;Riekse, R;Galasko, D
342例受试者接受了428次研究性腰椎穿刺，以进行脑脊液（CSF）生物标志物研究。受试者为67名阿尔茨海默病或轻度认知障碍（AD/MCI）患者和275名年龄在21至88岁之间的认知正常成年人。使用Sprotte 24 g无创脊椎穿刺针在侧卧位或坐位进行腰椎穿刺。收集了多达34 μ l的脑脊液。腰椎穿刺过程中的焦虑和疼痛采用视觉模拟量表进行评定。任何不良事件（11.7%）、具有临床意义的不良事件（3.97%）和典型的腰穿后头痛（PLPHA）（0.93%）的频率较低。腰椎穿刺后头痛的风险与年龄、性别、腰椎穿刺时的体位、脑脊液采集时间、腰椎穿刺后卧位休息时间无关。AD/MCI组腰椎穿刺后头痛的发生率（P = 0.03）低于其他任何受试者组。焦虑和疼痛评分较低，年轻受试者比老年人（P = 0.001）和AD/MCI受试者（P = 0.008）报告更多的焦虑，比老年正常受试者（P = 0.013）更多的疼痛。女性的疼痛评分高于男性（P = 0.006）。使用Sprotte 24 g脊柱穿刺针进行研究性腰椎穿刺，具有临床意义的不良事件发生率非常低，并且在所有年龄段的认知受损人群和认知正常成人中具有良好的可接受性。
Three hundred forty-two Subjects underwent 428 research lumbar punctures for Studies of cerebrospinal fluid (CSF) biomarkers. Subjects were 67 Alzheimer disease or mild cognitive impairment (AD/MCI) patients and 275 cognitively normal adults aged 21 to 88. Lumbar puncture was performed in the lateral decubitus or sitting position using the Sprotte 24g atraumatic spinal needle. Up to 34 ill] of cerebrospinal fluid were collected. Anxiety and pain experienced during lumbar puncture were rated on a visual analog scale. The frequency of any adverse event (11.7%), clinically significant adverse events (3.97%), and typical Post-lumbar puncture headache (PLPHA) (0.93%) was low. Risk of post-lumbar puncture headache was un-related to age, gender, position during lumbar puncture, till of cerebrospinal fluid collected, or minutes of recumbent rest following lumbar puncture. The frequency of post-lumbar puncture headache was lower in AD/MCI (P = 0.03) than any other subject group. Anxiety and pain ratings were low, Younger subjects reported more anxiety than old (P = 0.001) and AD/MCI subjects (P = 0.008) and more pain than older normal subjects (P = 0.013). Pain ratings for women were higher than those for men (P = 0.006). Using the Sprotte 24g spinal needle, research lumbar puncture can be performed with a very low rate of clinically significant adverse events and with good acceptability in cognitively impaired persons and cognitively normal adults Of all ages.