Interleukin 1 polymorphisms and intervertebral disc degeneration
Interleukin 1 polymorphisms and intervertebral disc degeneration
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DOI：
10.1097/01.ede.0000135179.04563.35
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发表时间：
2004-09-01
期刊：
影响因子：
5.4
通讯作者：
Riihimäki, H
中科院分区：
文献类型：
--
作者：
Solovieva, S;Kouhia, S;Riihimäki, H
背景：细胞外基质的酶分解和可能的局部炎症有助于椎间盘退变。我们研究了IL-1基因位点的多态性是否与腰椎间盘退变有关，以及职业性体力负荷对腰椎间盘退变的影响是否被多态性所改变。方法：对133名接受腰椎磁共振成像的中年男性进行基因型测定。参与者来自3种职业：40名机器司机，42名木匠，51名办公室职员。我们评估了髓核信号强度降低、椎间盘突出和椎间盘高度降低作为L2/L3-L5/S1椎间盘退变的迹象。结果：在il -1alpha（889）和IL-1betaT（3954）等位基因携带者中，椎间盘突出的比值比分别为2.4（95%可信区间= 1.2-4.8）和1.9（1.0-3.7）。与CC基因型相比，TT基因型的il -1 α基因型的椎间盘突出风险是CC基因型的3倍以上。结论：IL-1基因簇多态性可能影响椎间盘退变的发生风险。体力工作负荷的影响似乎被IL-1基因多态性所改变。
Background: Enzymatic breakdown of the extracellular matrix, and possibly local inflammation, contributes to intervertebral disc degeneration. We investigated whether polymorphisms within the IL-1 gene locus are associated with lumbar disc degeneration and whether the effect of occupational physical load on disc degeneration is modified by the polymorphisms.Methods: Genotypes were determined from 133 middle-aged men who underwent magnetic resonance imaging of the lumbar spine. The participants represented 3 occupations: 40 were machine drivers, 42 carpenters, and 51 office workers. We evaluated decreased signal intensity of the nucleus pulposus, disc bulges, and decreased disc height as signs of degeneration in the L2/L3-L5/S1 discs.Results: The odds ratio for disc bulges was 2.4 (95% confidence interval = 1.2-4.8) and 1.9 (1.0-3.7), in carriers of the IL-1alphaT(889) or IL-1betaT(3954) alleles, respectively. The TT genotype of the IL-1alpha gene carried more than 3-fold risk of disc bulges as compared with the CC genotype.Conclusions: IL-1 gene cluster polymorphisms could affect the risk of disc degeneration. The effect of physical workload seems to be modified by the IL-1 gene polymorphisms.