Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease
Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease
复制标题
DOI：
10.3109/00365529609095544
复制
发表时间：
1996-01-01
影响因子：
1.9
通讯作者：
Wiklund, I
中科院分区：
文献类型：
--
作者：
Dimenas, E;Carlsson, G;Wiklund, I
本文介绍了正常值与一系列用于上消化道疾病的生活质量问卷的相关性。参考值的推导通过确认问卷区分患者与健康对照的能力提供了重要贡献。使用两份自填问卷：心理总体健康指数（PGWB）和胃肠道症状评定量表（GSRS）。正常值是从由 4624 人组成的瑞典人群（参考组）中随机选择的样本中得出的。这些患者包括临床试验中的 900 多名胃食管反流病 (GORD) 患者。在参考组中，男性报告的幸福感明显高于女性，而女性报告的胃肠道症状比男性更明显。一般来说，较年轻的人和 60-70 岁的人群报告的健康状况最高。在胃肠道患者中，女性的得分低于男性，但报告的症状较多。随着年龄的增长，健康状况改善，症状减轻。尽管患者和参考组之间的健康和症状评分不同，但在年龄和性别方面观察到相似的模式。总之，结果表明正常对照组和 GORD 患者在性别和年龄方面存在差异。在临床研究中必须考虑这些方面。结果还支持生活质量仪器的辨别能力。
This article presents the relevance of norm values to a battery of Quality of Life questionnaires for use in upper gastrointestinal disorders. The derivation of reference values offers an important contribution by confirming the ability of the questionnaires to differentiate patients from healthy controls. Two self-administered questionnaires, the Psychological General Well-being (PGWB) index and the Gastrointestinal Symptom Rating Scale (GSRS) were used. The norm values were derived in a randomly selected sample from a Swedish population consisting of 4624 individuals (reference group). The patients comprised more than 900 patients with gastroesophageal reflux disease (GORD) included in clinical trials. In the reference group, males reported significantly higher values on well-being as compared with women, whereas women reported more pronounced gastrointestinal symptoms than men. Generally, the younger persons and the group aged 60-70 years reported the highest well-being Among gastrointestinal patients women scored lower and reported more symptoms than men. With increasing age, well-being improved and symptoms declined. Even though the well-being and symptoms scores differed between patient and the reference group similar patterns in terms of age and gender were observed. In summary, the results show that there are differences with respect to gender and age among normal controls as well as in GORD patients. These aspects have to be considered in clinical studies. The results also support the discriminative ability of the Quality of Life instruments.