Obesity in Men With Childhood ADHD: A 33-Year Controlled, Prospective, Follow-up Study
Obesity in Men With Childhood ADHD: A 33-Year Controlled, Prospective, Follow-up Study
复制标题
DOI：
10.1542/peds.2012-0540
复制
发表时间：
2013-06-01
期刊：
影响因子：
8
通讯作者：
Mannuzza, Salvatore
中科院分区：
文献类型：
--
作者：
Cortese, Samuele;Olazagasti, Maria A. Ramos;Mannuzza, Salvatore
目的：比较患有和不患有儿童注意力缺陷/多动障碍 (ADHD) 的成年男性的体重指数 (BMI) 和肥胖率。我们预测以下人群的 BMI 和肥胖率较高：(1) 患有儿童多动症的男性与没有儿童多动症的男性相比； (2) 患有持续性 ADHD 的男性与缓解型 ADHD 的男性； (3) 患有持续性或缓解性 ADHD 的男性与无儿童期 ADHD 的男性相比。 方法：患有儿童期 ADHD 的男性来自 207 名白人男孩（平均年龄为 8.3 岁），在平均年龄 18 (FU18)、25 (FU25) 和 41 岁 (FU41) 时进行盲法访谈。在 FU18 中，招募了 178 名没有 ADHD 的男孩。在 FU41 中，111 名患有儿童 ADHD 的男性和 111 名没有儿童 ADHD 的男性自我报告了自己的体重和身高。 结果：患有儿童 ADHD 的男性的 BMI（30.1 +/- 6.3 vs 27.6 +/- 3.9；P = 0.001）和肥胖率（41.4% vs 21.6%；P = 0.001）显着高于没有儿童 ADHD 的男性。在调整社会经济地位和终生精神障碍后，组间差异仍然显着。患有持续性 (n = 24) 和缓解 (n = 87) ADHD 的男性在 BMI 或肥胖率方面没有显着差异。即使在调整后，与没有儿童 ADHD 的男性相比，患有 ADHD 的男性的 BMI（B：2.86 [95% CI：1.22 至 4.50]）和肥胖率（比值比：2.99 [95% CI：1.55 至 5.77]）也显着较高。 结论：患有 ADHD 的儿童成年后肥胖的风险增加。 ADHD 缓解男性的 BMI 和肥胖率升高的研究结果需要重复。
OBJECTIVE: To compare BMI and obesity rates in fully grown men with and without childhood attention-deficit/hyperactivity disorder (ADHD). We predicted higher BMI and obesity rates in: (1) men with, versus men without, childhood ADHD; (2) men with persistent, versus men with remitted, ADHD; and (3) men with persistent or remitted ADHD versus those without childhood ADHD.METHODS: Men with childhood ADHD were from a cohort of 207 white boys (referred at a mean age of 8.3 years), interviewed blindly at mean ages 18 (FU18), 25 (FU25), and 41 years (FU41). At FU18, 178 boys without ADHD were recruited. At FU41, 111 men with childhood ADHD and 111 men without childhood ADHD self-reported their weight and height.RESULTS: Men with childhood ADHD had significantly higher BMI (30.1 +/- 6.3 vs 27.6 +/- 3.9; P = .001) and obesity rates (41.4% vs 21.6%; P = .001) than men without childhood ADHD. Group differences remained significant after adjustment for socioeconomic status and lifetime mental disorders. Men with persistent (n = 24) and remitted (n = 87) ADHD did not differ significantly in BMI or obesity rates. Even after adjustment, men with remitted (but not persistent) ADHD had significantly higher BMI (B: 2.86 [95% CI: 1.22 to 4.50]) and obesity rates (odds ratio: 2.99 [95% CI: 1.55 to 5.77]) than those without childhood ADHD.CONCLUSIONS: Children with ADHD are at increased risk of obesity as adults. Findings of elevated BMI and obesity rates in men with remitted ADHD require replication.