CONDITIONING AND CONTEXTUAL RETRIEVAL IN HIPPOCAMPAL RATS
CONDITIONING AND CONTEXTUAL RETRIEVAL IN HIPPOCAMPAL RATS
复制标题
DOI：
10.1037/0735-7044.105.4.499
复制
发表时间：
1991-08-01
影响因子：
1.9
通讯作者：
HONEY, RC
中科院分区：
文献类型：
--
作者：
GOOD, M;HONEY, RC
以大鼠为实验对象，通过3个实验研究了海马区在联想学习中的作用。无论是通过插入杠杆发出食物信号(实验1)，还是当听觉或视觉事件的呈现作为条件刺激(实验2)时，海马区大鼠的条件性反应的获得都受到了损害。实验2还评估了条件性反应习得缺陷反映了海马区受试者未能使用上下文线索提取关联信息的暗示。实验3表明，大鼠在学习简单的巴甫洛夫语境辨别时，海马区的大鼠没有受到损害。这一结果模式表明，海马体参与了更高级别的语境提取过程。
The role of the hippocampus in associative learning was investigated in 3 experiments with rats as subjects. Hippocampal rats were impaired in the acquisition of conditioned responding both when food was signaled by the insertion of a lever (Experiment 1) and when the presentation of auditory or visual events served as the conditioned stimuli (Experiment 2). Experiment 2 also evaluated the suggestion that deficits in the acquisition of conditioned responding reflect the failure of hippocampal subjects to use contextual cues to retrieve associative information. This experiment showed that hippocampal rats were impaired in learning that a given stimulus was reinforced in Context A but nonreinforced in Context B. Experiment 3 demonstrated that hippocampal rats were unimpaired in learning a simple Pavlovian contextual discrimination. This pattern of results suggests that the hippocampus is involved in a higher order contextual retrieval process.