Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis.
Anti-type II collagen antibodies are associated with early radiographic destruction in rheumatoid arthritis.
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DOI：
10.1186/ar3825
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发表时间：
2012-05-01
影响因子：
4.9
通讯作者：
Rönnelid J
中科院分区：
文献类型：
--
作者：
Mullazehi M;Wick MC;Klareskog L;van Vollenhoven R;Rönnelid J
我们以前曾报道，在RA诊断时，高水平的天然人II型胶原特异性抗体（抗CII）与并发的炎症症状相关，但与后来的炎症症状无关。这与体外CII/抗CII免疫复合物（IC）诱导的促炎细胞因子的产生有关。相反，抗环瓜氨酸肽抗体（抗CCP）与同一RA队列中的晚期炎症和晚期放射性破坏相关。因此，我们假设抗CII抗体也与早期糜烂有关。256例早期RA患者纳入研究。抗CII、抗CCP和抗突变瓜氨酸波形蛋白的基线水平用ELISA分析，类风湿因子水平用比浊法测定。使用32个关节Larsen侵蚀评分对基线、1年和2年后的手和脚的X光片进行量化。抗CII水平在RA队列中呈双峰分布，有一小组（3.1%，8/256）非常高的离群值，中位水平是健康对照组中位水平的87倍。使用与抗CII IC诱导的体外促炎细胞因子产生相关的离群值组的临界值，基线抗CII抗体与诊断时放射学损伤增加显著相关（p = 0.0486）。抗CII阳性患者在诊断时HAQ评分（p = 0.0303）、CRP（p = 0.0026）和ESR（p = 0.0396）也显著增加，但在随访期间没有增加。抗CII阳性受试者的中位年龄比抗CII阴性患者高12岁。与抗CCP相反，抗CII阳性的RA患者在基线时关节破坏和HAQ评分增加。因此，与抗CCP阳性RA患者中炎性/破坏性表型的晚期出现相比，抗CII表征早期炎性/破坏性表型。抗CII表型可能是老年急性发作RA的部分表型，预后较好。
We have previously reported that high levels of antibodies specific for native human type II collagen (anti-CII) at the time of RA diagnosis were associated with concurrent but not later signs of inflammation. This was associated with CII/anti-CII immune complex (IC)-induced production of pro-inflammatory cytokines in vitro. In contrast, anti-cyclic citrullinated peptide antibodies (anti-CCP) were associated both with late inflammation and late radiological destruction in the same RA cohort. We therefore hypothesized that anti-CII are also associated with early erosions. Two-hundred-and-fifty-six patients from an early RA cohort were included. Baseline levels of anti-CII, anti-CCP and anti-mutated citrullinated vimentin were analyzed with ELISA, and rheumatoid factor levels were determined by nephelometry. Radiographs of hands and feet at baseline, after one and after two years were quantified using the 32-joints Larsen erosion score. Levels of anti-CII were bimodally distributed in the RA cohort, with a small (3.1%, 8/256) group of very high outliers with a median level 87 times higher than the median for the healthy control group. Using a cut-off discriminating the outlier group that was associated with anti-CII IC-induced production of proinflammatory cytokines in vitro, baseline anti-CII antibodies were significantly (p = 0.0486) associated with increased radiographic damage at the time of diagnosis. Anti-CII-positive patient had also significantly increased HAQ score (p = 0.0303), CRP (p = 0.0026) and ESR (p = 0.0396) at the time of diagnosis but not during follow-up. The median age among anti-CII-positive subjects was 12 years higher than among the anti-CII-negative patients. In contrary to anti-CCP, anti-CII-positive patients with RA have increased joint destruction and HAQ score at baseline. Anti-CII thus characterizes an early inflammatory/destructive phenotype, in contrast to the late appearance of an inflammatory/destructive phenotype in anti-CCP positive RA patients. The anti-CII phenotype might account for part of the elderly acute onset RA phenotype with rather good prognosis.
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影响因子：
--
作者：
Mullazehi, Mohammed;Mathsson, Linda;Ronnelid, Johan
通讯作者：
Ronnelid, Johan
影响因子：
--
作者：
Bang, Holger;Egerer, Karl;Burmester, Gerd-R.
通讯作者：
Burmester, Gerd-R.
影响因子：
4.9
作者：
Mathsson L;Lampa J;Mullazehi M;Rönnelid J
通讯作者：
Rönnelid J
影响因子：
27.4
作者：
Mullazehi, Mohammed;Mathsson, Linda;Ronnelid, Johan
通讯作者：
Ronnelid, Johan
影响因子：
--
作者：
van der Woude, Diane;Young, Adam;van der Helm-van Mil, Annette H. M.
通讯作者：
van der Helm-van Mil, Annette H. M.