Megabladder mouse model of congenital obstructive nephropathy: genetic etiology and renal adaptation.
Megabladder mouse model of congenital obstructive nephropathy: genetic etiology and renal adaptation.
复制标题
DOI：
10.1007/s00467-013-2658-6
复制
发表时间：
2014-04
影响因子：
3
通讯作者：
McHugh, Kirk M.
中科院分区：
文献类型：
--
作者：
McHugh, Kirk M.
关键词：
Congenital obstructive nephropathy remains one of the leading causes of chronic renal failure in children. The direct link between obstructed urine flow and abnormal renal development and subsequent dysfunction represents a central paradigm of urogenital pathogenesis that has far-reaching clinical implications. Even so, a number of diagnostic, prognostic, and therapeutic quandaries still exist in the management of congenital obstructive nephropathy. Studies in our laboratory have characterized a unique mutant mouse line that develops in utero megabladder, variable hydronephrosis, and progressive renal failure. Megabladder mice represent a valuable functional model for the study of congenital obstructive nephropathy. Recent studies have begun to shed light on the genetic etiology of mgb −/− mice as well as the molecular pathways controlling disease progression in these animals.
登录
查看更多内容
影响因子：
19.6
作者：
Sanna-Cherchi, Simone;Ravani, Pietro;Ghiggeri, Gian Marco
通讯作者：
Ghiggeri, Gian Marco
影响因子：
4.5
作者：
Kousidis, Grigorios;Thomas, David F. M.;Feather, Sally
通讯作者：
Feather, Sally
影响因子：
13.6
作者：
Delle, Humberto;Rocha, Jose Roberto C.;Noronha, Irene L.
通讯作者：
Noronha, Irene L.
影响因子：
3.7
作者：
Becknell, Brian;Carpenter, Ashley R.;McHugh, Kirk M.
通讯作者：
McHugh, Kirk M.
影响因子：
3.5
作者：
deKok, YJM;Vossenaar, ER;Cremers, FPM
通讯作者：
Cremers, FPM