Environmental origins of congenital heart disease: The heart-placenta connection
Environmental origins of congenital heart disease: The heart-placenta connection
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DOI：
10.1016/j.siny.2013.05.003
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发表时间：
2013-10-01
影响因子：
3
通讯作者：
Linask, Kersti K.
中科院分区：
文献类型：
--
作者：
Huhta, James;Linask, Kersti K.
虽然哺乳动物胚胎在子宫内受到很好的保护，但环境化学品、药物和母体营养失衡会干扰妊娠早期指导胎盘和胚胎发育的调节途径。胚胎细胞在细胞特化和分化阶段最容易受到环境影响。由于生化分化往往先于形态结果，对环境化学物质的敏感期先于可见的形态发生效应。药物和其他环境因素破坏胚胎发育并诱发心脏异常的细胞机制仍不清楚。(C)2013由Elsevier Ltd.出版
Although the mammalian embryo is well protected in the uterus, environmental chemicals, drugs, and maternal nutritional imbalances can interfere with regulatory pathways directing placental and embryonic development early in gestation. Embryonic cells are most susceptible to environmental influences during cellular specification and differentiation stages. Because biochemical differentiation precedes morphological outcome often by days, the period of susceptibility to environmental chemicals expectedly precedes visible morphogenic effects. The cellular mechanisms by which drugs and other environmental factors disrupt embryonic development and induce cardiac abnormalities have remained undefined. (C) 2013 Published by Elsevier Ltd.