Expression of the highly conserved RNA binding protein KOC in embryogenesis
Expression of the highly conserved RNA binding protein KOC in embryogenesis
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DOI：
10.1016/s0925-4773(99)00160-4
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发表时间：
1999-10-01
影响因子：
2.6
通讯作者：
Gress, TM
中科院分区：
文献类型：
--
作者：
Mueller-Pillasch, F;Pohl, B;Gress, TM
在癌症中高表达的人类KOC基因显示出RNA结合蛋白的典型结构特征。我们分析了不同胎龄小鼠胚胎中 KOC 的时空表达模式。 KOC 的表达在早期阶段似乎普遍存在。在妊娠后期，最高的 KOC 表达出现在肠道、胰腺、肾脏和发育中的大脑中。将青蛙发育过程中 KOC 的表达模式与其爪蟾同源物 Vg1-RBP 进行比较。在这些器官中发现了类似的表达，表明同源蛋白在胚胎发育中具有重要的功能作用。 (C) 1999 Elsevier Science Ireland Ltd. 保留 AII 权利。
The human KOC gene which is highly expressed in cancer shows typical structural features of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC in mouse embryos at different gestational ages. The expression of KOC seems to be ubiquitous at early stages. During advanced gestation highest KOC expression occurs in the gut, pancreas, kidney, and in the developing brain. The expression pattern of KOC was compared to its Xenopus homologue Vg1-RBP during frog development. Similar expression was found in these organs suggesting an important functional role of the homologous proteins in embryonic development. (C) 1999 Elsevier Science Ireland Ltd. AII rights reserved.