TAY-SACHS DISEASE - PROGRESSION OF CHANGES ON NEUROIMAGING IN 4 CASES
TAY-SACHS DISEASE - PROGRESSION OF CHANGES ON NEUROIMAGING IN 4 CASES
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DOI：
10.1007/bf00598955
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发表时间：
1992-11-01
期刊：
影响因子：
2.8
通讯作者：
KUROKAWA, T
中科院分区：
文献类型：
--
作者：
FUKUMIZU, M;YOSHIKAWA, H;KUROKAWA, T
神经放射学结果在4例患者与泰-萨克斯病的临床过程中的三个阶段进行了描述。基底节和大脑白色物质在计算机断层扫描上显示低密度，在T2加权磁共振成像上显示高信号。在第一和第二阶段，尾状核特征性地增大并突出到侧脑室中。脑白色物质在CT上呈低密度，第二至第三时相范围不同，最后时相全脑萎缩。因此，中枢神经系统参与的疾病可能开始在基底节以及在大脑白色物质。
The neuroradiological findings in four patients with Tay-Sachs disease are described in three phases of the clinical course. The basal ganglia and cerebral white matter show low density on computed tomography and high signal intensity on T2-weighted magnetic resonance imaging in the initial phase. The caudate nuclei are characteristically enlarged and protrude into the lateral ventricles in the first and second phases. The cerebral white matter shows low density on the CT which varies in extent from the second to third phases, and the whole brain becomes atrophic in the last phase. Thus, central nervous system involvement in the disease may begin in basal ganglia as well as in cerebral white matter.