Analgesic effects of lappaconitine in leukemia bone pain in a mouse model.
Analgesic effects of lappaconitine in leukemia bone pain in a mouse model.
复制标题
高乌头碱对小鼠白血病骨痛模型的镇痛作用
作者：
Zhu XC;Ge CT;Wang P;Zhang JL;Yu YY;Fu CY
骨痛是癌症患者常见且严重的症状。本研究采用K562白血病骨痛小鼠模型，观察高乌甲素的镇痛作用。结果表明，高乌甲素治疗后15、17、19 d可有效降低自发痛评分值，恢复K562细胞诱导的斜板实验降低程度，恢复K562细胞诱导的机械缩足阈和热缩足潜伏期至正常水平。高乌甲素镇痛作用的分子机制可能与影响内源性阿片系统基因（POMC、PENK和莫尔）以及凋亡相关基因（Xip、Smac、Bim、NF-κB和p53）的表达水平有关。高乌甲素可能成为治疗白血病骨痛的一种新的镇痛药。
Bone pain is a common and severe symptom in cancer patients. The present study employed a mouse model of leukemia bone pain by injection K562 cells into tibia of mouse to evaluate the analgesic effects of lappacontine. Our results showed that the lappaconitine treatment at day 15, 17 and 19 could effectively reduce the spontaneous pain scoring values, restore reduced degree in the inclined-plate test induced by injection of K562 cells, as well as restore paw mechanical withdrawal threshold and paw withdrawal thermal latency induced by injection of K562 cells to the normal levels. Additionally, the molecular mechanisms of lappaconitine’s analgesic effects may be related to affect the expression levels of endogenous opioid system genes (POMC, PENK and MOR), as well as apoptosis-related genes (Xiap, Smac, Bim, NF-κB and p53). Our present results indicated that lappaconitine may become a new analgesic agent for leukemia bone pain management.
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影响因子：
2.7
作者：
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通讯作者：
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4.2
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3.7
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8.8
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