Decreased high-density lipoprotein (HDL) particle size, preβ-, and large HDL subspecies concentration in Finnish low-HDL families -: Relationship with intima-media thickness
Decreased high-density lipoprotein (HDL) particle size, preβ-, and large HDL subspecies concentration in Finnish low-HDL families -: Relationship with intima-media thickness
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DOI：
10.1161/01.atv.0000209577.04246.c0
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发表时间：
2006-04-01
影响因子：
8.7
通讯作者：
Taskinen, MR
中科院分区：
文献类型：
--
作者：
Watanabe, H;Söderlund, S;Taskinen, MR
目的——高密度脂蛋白（HDL）胆固醇与冠心病（CHD）的风险呈负相关。 HDL 亚种的精确抗动脉粥样硬化机制尚未完全阐明。我们研究了芬兰低 HDL 胆固醇和早发冠心病家庭中颈动脉内膜中层厚度 (IMT) 与 HDL 亚种分布之间的关系。方法和结果 - 共有 148 名芬兰低 HDL 家庭成员和 133 名健康对照受试者参与了我们的研究。受影响的家庭成员中的 HDL 颗粒尺寸明显更小（HDL
Objective-High-density lipoprotein (HDL) cholesterol correlates inversely with the risk of coronary heart disease (CHD). The precise antiatherogenic mechanisms of HDL subspecies are not thoroughly elucidated. We studied the relationship between carotid intima-media thickness (IMT) and HDL subspecies distribution in Finnish families with low HDL cholesterol and premature CHD.Methods and Results-Altogether, 148 members of Finnish low-HDL families and 133 healthy control subjects participated in our study. HDL particle size was significantly smaller in affected family members (HDL