Red cell membrane sodium transport: possible genetic role and use in identifying patients at risk of essential hypertension.
Red cell membrane sodium transport: possible genetic role and use in identifying patients at risk of essential hypertension.
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红细胞膜钠转运：可能的遗传作用和在识别原发性高血压风险患者中的用途。
DOI：
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发表时间：
1990
影响因子：
5.2
通讯作者：
Wcin 1EH
中科院分区：
文献类型：
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作者：
E. Deal;V. Shah;G. Goodenough;M. Dillon;Wcin 1EH
为探讨原发性高血压家族史对红细胞膜钠转运异常的影响，对28例原发性高血压儿童及其家系进行了研究。在15个家庭中，父母一方或双方患有原发性高血压或有强烈的家族史。在13个家庭中，父母都没有原发性高血压或阳性家族史。有原发性高血压家族史的儿童与无高血压家族史的儿童比较，差异有统计学意义。数值表示为平均值（SD）：细胞内钠浓度（mmol/l细胞）8.19（2.18）与6.41相比（0.98）;钠外排速率常数0.4873（0.1379）和0.5831（0.1104）;钠-钾ATP酶泵位点数（BMax）（nmol/l细胞）分别为7.96（1.71）和9.56（1.7）。当排除指数高血压儿童和血压正常的兄弟姐妹与无高血压家族史进行比较时，也发现了显着差异。这些数据表明，异常红细胞膜钠转运具有家族性成分，虽然它不是由高血压引起的，但它可能是其发展过程中最早的病理生理学步骤，也许可以识别儿童原发性高血压的风险。
To investigate the influence of a family history of essential hypertension on abnormalities of red cell membrane sodium transport, 28 hypertensive children and their families were studied. In 15 families one or both parents had either essential hypertension or a strong family history. In 13 families neither parent had essential hypertension or a positive family history. There were significant differences between the children with a positive family history of essential hypertension compared with those without. Values are expressed as mean (SD): intracellular sodium concentration (mmol/l cells) 8.19 (2.18) compared with 6.41 (0.98); sodium efflux rate constant 0.4873 (0.1379) compared with 0.5831 (0.1104); and numbers of sodium-potassium ATPase pump sites (BMax) (nmol/l cells) 7.96 (1.71) compared with 9.56 (1.7). Significant differences were also found when the index hypertensive children were excluded and the normotensive siblings with and without hypertensive family histories were compared. These data suggest that abnormal red cell membrane sodium transport has a familial component, and although it is not caused by the hypertension it may be the earliest pathophysiological step in its development, perhaps allowing the identification of children at risk of essential hypertension.