Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models
Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models
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DOI：
10.1177/0271678x16663947
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发表时间：
2017-06-01
影响因子：
6.3
通讯作者：
Valable, Samuel
中科院分区：
文献类型：
--
作者：
Chakhoyan, Ararat;Corroyer-Dulmont, Aurelien;Valable, Samuel
使用Carbogen改善治疗以缓解胶质母细胞瘤的缺氧，但收效甚微。我们的假设是，Carbogen的最终益处取决于血管扩张的能力。我们用核磁共振检查了Carbogen治疗后脑血容量分数、血氧饱和度和血氧水平依赖信号的变化。这些分析是在两个被认为具有不同血管模式的胶质瘤异种移植模型(U87和U251)中进行的。Carbogen增加对侧组织的脑血容量分数、血氧饱和度和血氧水平依赖信号。在肿瘤核心和瘤周区域，变化取决于血管扩张能力，而不是静息状态下的脑血容量。在血运丰富的U87肿瘤中，与血运较少的U251肿瘤相比，Carbogen诱导的脑血容量分数和血氧饱和度增加得更多。血氧水平依赖的信号显示U251肿瘤相对于对侧组织有延迟反应。此外，我们强调了U251肿瘤中多个隔室(肿瘤核心、边缘和瘤周区域)共存时，取决于脑血容量分数、血氧饱和度和血氧水平的相当大的异质性。最后，我们的研究强调了不同胶质母细胞瘤模型中血流/代谢相互作用的复杂性。在临床试验中，为了减轻肿瘤内缺氧，应考虑到这些不规则性。
The alleviation of hypoxia in glioblastoma with carbogen to improve treatment has met with limited success. Our hypothesis is that the eventual benefits of carbogen depend on the capacity for vasodilation. We examined, with MRI, changes in fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in response to carbogen. The analyses were performed in two xenograft models of glioma (U87 and U251) recognized to have different vascular patterns. Carbogen increased fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in contralateral tissues. In the tumor core and peritumoral regions, changes were dependent on the capacity to vasodilate rather than on resting fractional cerebral blood volume. In the highly vascularised U87 tumor, carbogen induced a greater increase in fractional cerebral blood volume and blood oxygen saturation in comparison to the less vascularized U251 tumor. The blood oxygenation level dependent signal revealed a delayed response in U251 tumors relative to the contralateral tissue. Additionally, we highlight the considerable heterogeneity of fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent within U251 tumor in which multiple compartments co-exist (tumor core, rim and peritumoral regions). Finally, our study underlines the complexity of the flow/metabolism interactions in different models of glioblastoma. These irregularities should be taken into account in order to palliate intratumoral hypoxia in clinical trials.