Non-A, non-B posttransfusion hepatitis--a decade later.
Non-A, non-B posttransfusion hepatitis--a decade later.
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非甲非乙型输血后肝炎——十年后。
DOI：
10.1016/s0016-5085(85)80087-1
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发表时间：
1985
期刊：
影响因子：
29.4
通讯作者：
Gitnick,GL
中科院分区：
文献类型：
--
作者：
Koretz,RL;Stone,O;Mousa,M;Gitnick,GL
本文对1972 ~ 1978年发生的非甲非乙型输血后肝炎69例进行了随访。在46名患者（67%）中观察到慢性肝炎（根据生化标准定义），其中大多数随后未能解决异常。慢性肝炎是非甲、非乙型输血后肝炎的后遗症，在血库改为所有志愿献血者的政策后，这种情况较少发生：（然而，这种关联可能由其他共存因素解释。）在非甲非乙型输血后肝炎慢性期，丙氨酸氨基转移酶水平比天冬氨酸氨基转移酶水平更可能异常。通过精算手段计算出，6-10年后发展正常酶的概率为0.47。然而，尽管生化疾病的发病率很高，但实际上所有患者都没有症状。在这些患者中，有4例获得了肝硬化的组织学证据，但最多只有2例患者有肝衰竭的临床证据。
We have followed up 69 patients who developed non-A, non-B posttrans fusion hepatitis in 1972-1978. Chronic hepatitis, defined by biochemical criteria, was observed in 46 patients (67%), the majority of whom subsequently failed to resolve the abnormalities. Chronic hepatitis was a sequela of non-A, non-B posttrans f usion hepatitis less often after the blood bank changed to a policy of all volunteer donors: (However, this association may be explained by other coexistent factors.) The alanine aminotransferase level was more likely to be abnormal than the aspartate aminotransferase level during the chronic phase of non-A, non-B posttrans fusion hepatitis. By actuarial means it was calculated that the probability of developing normal enzymes after 6-10 yr was 0.47. However, in spite of this high incidence of biochemical disease, virtually all of the patients have remained asymptomatic. Histologic evidence of cirrhosis has been obtained in 4 of these patients, but in only 2 patients at most has clinical evidence of hepatic failure supervened.