A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population
复制标题
DOI：
10.1038/ng.2353
复制
发表时间：
2012-08-01
期刊：
影响因子：
30.8
通讯作者：
Kohno, Takashi
中科院分区：
文献类型：
--
作者：
Shiraishi, Kouya;Kunitoh, Hideo;Kohno, Takashi
Lung adenocarcinoma is the most common histological type of lung cancer, and its incidence is increasing worldwide. To identify genetic factors influencing risk of lung adenocarcinoma, we conducted a genome-wide association study and two validation studies in the Japanese population comprising a total of 6,029 individuals with lung adenocarcinoma (cases) and 13,535 controls. We confirmed two previously reported risk loci, 5p15.33 (rs2853677, P-combined = 2.8 x 10(-40), odds ratio (OR) = 1.41) and 3q28 (rs10937405, P-combined = 6.9 x 10(-17), OR = 1.25), and identified two new susceptibility loci, 17q24.3 (rs7216064, P-combined = 7.4 x 10(-11), OR = 1.20) and 6p21.3 (rs3817963, P-combined = 2.7 x 10(-10), OR = 1.18). These data provide further evidence supporting a role for genetic susceptibility in the development of lung adenocarcinoma.
