The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome
The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome
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DOI：
10.3109/01443615.2010.546906
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发表时间：
2011-01-01
影响因子：
1.3
通讯作者：
Sahin, Y.
中科院分区：
文献类型：
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作者：
Ozgun, M. T.;Uludag, S.;Sahin, Y.
本研究的目的是比较肥胖PCOS患者和非肥胖PCOS患者的卵胞浆内单精子注射（ICSI）结局和促性腺激素剂量。这项随访研究比较了肥胖PCOS女性（BMI >= 30 kg/m2）与非肥胖PCOS女性（BMI < 30 kg/m2）的ICSI结局。肥胖（n=18）和非肥胖（n=26）PCOS妇女接受长方案垂体抑制，卵巢刺激和ICSI新鲜胚胎移植。肥胖PCOS患者需要更高剂量的促性腺激素（2994 IU vs 1719 IU; p < 0.001）。肥胖妇女的流产率显著高于非肥胖PCOS妇女（60% vs 6.7%，p=0.002）。我们的研究结果是有价值的咨询夫妇开始前的辅助生殖技术（ART）。
The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI >= 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n=18) and non-obese (n=26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p=0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).