The status of antimicrobial resistance in Taiwan among gram-negative pathogens: the Taiwan surveillance of antimicrobial resistance (TSAR) program, 2000
The status of antimicrobial resistance in Taiwan among gram-negative pathogens: the Taiwan surveillance of antimicrobial resistance (TSAR) program, 2000
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DOI：
10.1016/j.diagmicrobio.2003.10.005
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发表时间：
2004-03-01
影响因子：
2.9
通讯作者：
Ho, M
中科院分区：
文献类型：
--
作者：
Lauderdale, TL;McDonald, LC;Ho, M
在一项全国性的抗菌素耐药性监测（台湾抗菌素耐药性监测，TSAR）中，在2000年的三个月内（TSAR II），从台湾21个医疗中心和区域医院收集了分离株。本报告总结了TSAR II收集的7种常见革兰氏阴性杆菌（大肠埃希菌、肺炎克雷伯菌、粘质沙雷菌、奇异变形杆菌、阴沟肠杆菌、铜绿假单胞菌和鲍曼不动杆菌）的敏感性数据，并通过流行病学因素和1998年（TSAR I）收集的分离株以及国际监测研究的数据比较了选定的关键耐药形式。5种肠杆菌科细菌对台湾地区常用的一线抗菌药物如氨苄西林的耐药率为78%。大肠埃希菌、奇异变形杆菌中庆大霉素的检出率为68%;肺炎链球菌感染率为66%。粘质沙雷氏菌）、甲氧苄啶/磺胺甲恶唑（29%）; pneumoniae的比例高达70%，其中有几个国家的比例高于其他国家。对某些广谱抗菌药物的耐药性在台湾也比大多数西方国家更严重，如头孢他啶耐药的A。鲍曼不动杆菌（73%）和耐环丙沙星E.大肠杆菌（12%）。地理区域和标本类型的差异与TSAR II中某些形式的耐药相关;然而，耐药问题不仅在医疗中心而且在台湾各地的区域医院的住院患者和门诊患者中普遍存在。(C)2004爱思唯尔公司All rights reserved.
In a nationwide surveillance of antimicrobial resistance (Taiwan Surveillance of Antimicrobial Resistance, TSAR), isolates were collected from 21 medical centers and regional hospitals throughout Taiwan over a three-month period in 2000 (TSAR II). This report summarizes susceptibility data of 7 common Gram-negative bacilli (Escherichia coli, Klebsiella pneumoniae, Serratia marcescens, Proteus mirabilis, Enterobacter cloacae, Pseudomonas aeruginosa, and Acinetobacter baumannii) in the TSAR II collection and compared selected key forms of resistance by epidemiologic factors and with isolates collected in 1998 (TSAR I) as well as with data from international surveillance studies. Resistance of the 5 Enterobacteriaceae species to most of the commonly prescribed "first-line" antimicrobials in Taiwan, such as ampicillin (78% in E. coli, 68% in P. mirabilis), gentamicin (19% in K. pneumonia to 66% in S. marcescens), and trimethoprim/sulfamethoxazole (29% in K. pneumoniae to 70% in P. mirabilis), was high, several of which are higher than other countries. Resistance to certain broad-spectrum antimicrobials is also more acute in Taiwan than most Western countries, such as ceftazidime resistant A. baumannii (73%) and ciprofloxacin resistant E. coli (12%). Differences in geographic regions and specimen types were associated with certain forms of resistance in TSAR II; however, the resistance problem is prevalent among both inpatients and outpatients of not only medical centers but also regional hospitals throughout Taiwan. (C) 2004 Elsevier Inc. All rights reserved.