THE WISCONSIN EPIDEMIOLOGIC-STUDY OF DIABETIC-RETINOPATHY .14. 10-YEAR INCIDENCE AND PROGRESSION OF DIABETIC-RETINOPATHY
THE WISCONSIN EPIDEMIOLOGIC-STUDY OF DIABETIC-RETINOPATHY .14. 10-YEAR INCIDENCE AND PROGRESSION OF DIABETIC-RETINOPATHY
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DOI：
10.1001/archopht.1994.01090210105023
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发表时间：
1994-09-01
影响因子：
--
通讯作者：
CRUICKSHANKS, KJ
中科院分区：
文献类型：
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作者：
KLEIN, R;KLEIN, BEK;CRUICKSHANKS, KJ
目的：研究糖尿病视网膜病变的10年发病率和进展。设计：基于人群的发病率研究。参与者：765名在30岁之前诊断的胰岛素使用糖尿病患者，251名在30岁或以上诊断的胰岛素使用糖尿病患者，以及282名在30岁或以上诊断的非胰岛素使用糖尿病患者，他们参加了基线、LF-年、主要结果测量：10年任何视网膜病变的发病率，视网膜病变的进展，以及增殖性视网膜病变的进展通过使用改良的Airlie House分类和早期治疗糖尿病视网膜病变研究严重性方案的立体彩色眼底照片的掩蔽分级来检测。视网膜病变的10年发病率（89%、79%和67%），视网膜病变进展（76%、69%和53%），并进展为增殖性视网膜病变（30%，24%和10%）在30岁之前诊断的组中最高，在30岁或以上诊断的胰岛素服用组中居中，在非胰岛素服用组中最低，分别增殖性视网膜病变的风险增加与基线时更严重的视网膜病变相关。结论：这些数据表明，相对较高的10年率的发病率和视网膜病变的进展，尽管在糖尿病治疗的变化，有糖尿病视网膜病变的发病率和进展变化不大，在10年的研究期间。
Objective: To examine the 10-year incidence and progression of diabetic retinopathy.Design: Population-based incidence study.Participants: Seven hundred sixty-five insulin-taking diabetic persons diagnosed before age 30 years, 251 insulin-taking diabetic persons diagnosed at age 30 years or older, and 282 non-insulin-taking diabetic persons diagnosed at age 30 years or older who participated in baseline, LF-year, and 10-year follow-up examinations.Main Outcome Measures: The 10-year incidence of any retinopathy, progression of retinopathy, and progression to proliferative retinopathy were detected by masked grading of stereoscopic color fundus photographs using the modified Airlie House classification and the Early Treatment Diabetic Retinopathy Study severity scheme.Results: The 10-year incidence of retinopathy (89%, 79%, and 67%), progression of retinopathy (76%, 69%, and 53%), and progression to proliferative retinopathy (30%, 24%, and 10%) were highest in the group diagnosed before age 30 years, intermediate in the insulin-taking group diagnosed at age 30 years or older, and lowest in the non-insulin-taking group, respectively. Increased risk of proliferative retinopathy was associated with more severe retinopathy at baseline.Conclusions: These data suggest relatively high 10-year rates of incidence and progression of retinopathy, and despite changes in the treatment of diabetes, there has been little change in the incidence and progression of diabetic retinopathy during the 10-year study period.