Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome
Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome
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DOI：
10.1016/s0002-9149(99)00458-0
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发表时间：
1999-10-15
影响因子：
2.8
通讯作者：
Timothy, K
中科院分区：
文献类型：
--
作者：
Moss, AJ;Robinson, JL;Timothy, K
急性听觉刺激和游泳活动常与长QT综合征（LQTS）患者的晕厥、心脏骤停和死亡有关。研究人群涉及195例发生与大声噪音（n = 77）或游泳活动（n = 118）相关的索引心脏事件的患者。与大声听觉刺激相关事件的患者在索引事件时年龄较大，并且比在游泳相关活动期间经历事件的患者更可能是女性。发生与大声噪声相关的指标事件的患者可能发生与听觉刺激相关的后续事件;发生与游泳相关的指标事件的患者可能发生与游泳或体育活动相关的复发性事件。听觉和游泳和/或体力活动相关事件的家族模式是明显的。25例患者的基因型分析显示，不同基因型的心脏事件指数分布有显著差异（p
Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS), We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with Loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident, Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p