Variable levels of plasma catecholamines and dopamine beta-hydroxylase in hemodialysis patients.
Variable levels of plasma catecholamines and dopamine beta-hydroxylase in hemodialysis patients.
复制标题
血液透析患者血浆儿茶酚胺和多巴胺β-羟化酶的水平存在差异。
作者：
C. Corder;J. Sharma;R. Mcdonald
测定维持性血液透析患者血浆去甲肾上腺素(NE)、肾上腺素(EPI)、多巴胺(DPM)、多巴胺β-羟基酶(DBH)和肾素水平。透析前NE、EPI和DPM浓度分别为29、7.3和4.8pg/ml，低于正常水平。直立位30min时NE水平升高至100pg/ml。在透析后期间也测量了血药浓度，与正常受试者大致相同，但低于之前公布的血液透析患者的值。在透析前阶段，NE和肾素在直立体位时相关。结论：维持性血液透析可以在血浆儿茶酚胺水平不发生大的扭曲的情况下进行。
Plasma norepinephrine (NE), epinephrine (EPI), dopamine (DPM), dopamine beta-hydroxylase (DBH), and renin were measured in patients undergoing maintenance hemodialysis. The predialysis NE, EPI, and DPM concentrations were lower than normal at 29, 7.3 and 4.8 pg/ml, respectively. The NE level increased in the erect posture to 100 pg/ml at 30 min. Levels were also measured during the postdialysis period, and were approximately the same as in normal subjects, but lower than previously published values for patients undergoing hemodialysis. In the predialysis period, NE and renin correlated upon assumption of the upright posture. It is concluded that maintenance hemodialysis can be carried out without a major distortion of the plasma catecholamine levels.