Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
Temporal and spatial dynamics of human immunodeficiency virus type 1 circulating recombinant forms 08_BC and 07_BC in Asia
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DOI：
10.1128/jvi.00399-08
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发表时间：
2008-09-01
影响因子：
5.4
通讯作者：
Takebe, Yutaka
中科院分区：
文献类型：
--
作者：
Tee, Kok Keng;Pybus, Oliver G.;Takebe, Yutaka
人类免疫缺陷病毒1型（HIV-1）CRF08_BC和CRF07_BC是B'和C亚型的两种主要重组体。尽管它们在中国产生了巨大的流行影响，但它们的迁移模式和分化时间仍然未知。对来自中国、印度和缅甸不同地点的代表 CRF08_BC、CRF07_BC 和 C 亚型毒株的 228 个 HIV-1 序列进行了系统发育和群体遗传分析。在各种进化模型下，使用贝叶斯马尔可夫链蒙特卡罗框架估计了基因组特定的进化速率和分化时间。 CRF08_BC起源于1990.3年（95%可信区域[CR]，1988.6至1991.9）云南省，1995年左右传播到广西（南部）和辽宁（东北）。在广西地区内，CRF08_BC在1997年至1998年间从百色市（西部）继续向东扩展至宾阳（中部），随后蔓延进入凭祥周边 1999年在南方，吸毒者主要通过注射方式吸毒。此外，CRF07_BC 在 1993.3（95% CR，1991.2 至 1995.2）与其共同祖先分离，然后于 1990 年代末越过边境进入台湾南部。系统发育分析表明CRF08_BC和CRF07_BC的起源都可以追溯到云南。印度 C 亚型谱系的亲本可能于 1981.2 年左右进入中国（95% CR，1976.7 至 1985.9）。使用多个不连锁基因座模型，我们还表明，本研究中计算的分歧日期可能不会受到不同谱系之间亚型内重组的显着影响。这是第一个描述东亚艾滋病毒/艾滋病时空动态的系统动力学研究。
Human immunodeficiency virus type 1 (HIV-1) CRF08_BC and CRF07_BC are two major recombinants descended from subtypes B ' and C. Despite their massive epidemic impact in China, their migration patterns and divergence times remain unknown. Phylogenetic and population genetic analyses were performed on 228 HIV-1 sequences representing CRF08_BC, CRF07_BC, and subtype C strains from different locations across China, India, and Myanmar. Genome-specific rates of evolution and divergence times were estimated using a Bayesian Markov chain Monte Carlo framework under various evolutionary models. CRF08_BC originated in 1990.3 (95% credible region [CR], 1988.6 to 1991.9) in Yunnan province before spreading to Guangxi (south) and Liaoning (northeast) around 1995. Inside Guangxi region, the eastward expansion of CRF08_BC continued from Baise city (west) to Binyang (central) between 1997 and 1998 and later spread into Pingxiang around 1999 in the south, mainly through injecting drug users. Additionally, CRF07_BC diverged from its common ancestor in 1993.3 (95% CR, 1991.2 to 1995.2) before crossing the border into southern Taiwan in late 1990s. Phylogenetic analysis indicates that both CRF08_BC and CRF07_BC can trace their origins to Yunnan. The parental Indian subtype C lineage likely entered China around 1981.2 (95% CR, 1976.7 to 1985.9). Using a multiple unlinked locus model, we also showed that the dates of divergence calculated in this study may not be significantly affected by intrasubtype recombination among different lineages. This is the first phylodynamic study depicting the spatiotemporal dynamics of HIV/AIDS in East Asia.