Relation of obesity to clustering of cardiovascular disease risk factors in children and young adults. The Bogalusa Heart Study.
Relation of obesity to clustering of cardiovascular disease risk factors in children and young adults. The Bogalusa Heart Study.
复制标题
肥胖与儿童和年轻人心血管疾病危险因素聚集的关系。
DOI：
10.1093/oxfordjournals.aje.a114543
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发表时间：
1987
影响因子：
5
通讯作者：
Berenson,GS
中科院分区：
文献类型：
--
作者：
Smoak,CG;Burke,GL;Webber,LS;Harsha,DW;Srinivasan,SR;Berenson,GS
1981年9月至1983年9月在路易斯安那州Bogatusa的3，503名5-24岁的受试者中调查了收缩压、空腹胰岛素、低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（（LDL-C + VLDL-C）/HDL-C）与肥胖的关系。风险比（RR）计算为风险因素变量处于上三分位数的受试者数量除以预期数量。这些变量显示出很强的聚集性（RR = 3.1）;然而，在调整肥胖后，收缩压、（LDL-C + VLDL-C）/HDL-C和胰岛素的聚集性降低（RR = 1.3）。瘦的受试者（肥胖的下三分位数）显示出比预期更少的聚集（RR = 0.4），而更多的肥胖受试者（肥胖的上三分位数）具有比预期更大的聚集（RR = 3.1）。此外，躯干脂肪沉积（肩胛下皮褶）比肢体脂肪沉积（三头肌皮褶）对高水平聚集的影响更大。由于肥胖与儿童和年轻人的危险因素变量的聚集有关，因此预防早期肥胖的发生对降低晚年冠心病的风险可能很重要。
The relation of obesity to clustering of systolic blood pressure, fasting insulin, and ratio of low and vely low density lipoprotein cholesterol to high density lipoprotein cholesterol ((LDL-C + VLDL-C)/HDL-C) was investigated in 3,503 subjects aged 5–24 years in Bogatusa, Louisiana, from September 1981 to September 1983. Risk ratios (RR) were calculated as the number of subjects with risk factor variables in the upper tertile divided by the expected number. The variables showed strong clustering (RR = 3.1); however, after adjusting for obesity, clustering of systolic pressure, (LDL-C + VLDL-C)/HDL-C, and insulin was reduced (RR = 1.3). Lean subjects (lower tertile of obesity) showed less clustering than expected (RR = 0.4), while more obese subjects (upper tertile of obesity) had greater clustering than expected (RR = 3.1). Furthermore, trunk fat deposition (subscapular skinfold) had a greater impact on clustering at high levels than limb fat deposition (triceps skinfold). Since obesity is related to clustering of risk factor variables in children and young adults the prevention of the onset of obesity In early life may be important to reducing the risk of coronary heart disease in later life.