INTEGRATED BACKSCATTER AND INTIMA-MEDIA THICKNESS OF THE THORACIC AORTA EVALUATED BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN HYPERCHOLESTEROLEMIC PATIENTS: EFFECT OF PITAVASTATIN THERAPY
INTEGRATED BACKSCATTER AND INTIMA-MEDIA THICKNESS OF THE THORACIC AORTA EVALUATED BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN HYPERCHOLESTEROLEMIC PATIENTS: EFFECT OF PITAVASTATIN THERAPY
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DOI：
10.1016/j.ultrasmedbio.2008.08.011
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发表时间：
2009-02-01
影响因子：
2.9
通讯作者：
Minatoguchi, Shinya
中科院分区：
文献类型：
--
作者：
Ono, Koji;Kawasaki, Masanori;Minatoguchi, Shinya
强亲脂性他汀类药物（匹伐他汀）对胸主动脉的作用尚未阐明。本研究的目的是通过经食管超声心动图（TEE）评价匹伐他汀（P）治疗对胸主动脉斑块成分和形态的影响，并阐明该治疗对高胆固醇血症患者中膜和内膜的影响。对32例高胆固醇血症患者的64个胸主动脉中膜和64个内膜进行了研究。分别于P治疗或饮食（D）治疗前、后7 mo测量胸主动脉壁的校正背向散射积分（c-IRS）值和同一部位的内膜中层厚度（IMT）。此外，在168例无高胆固醇血症的患者中测量了培养基中的c-IBS值，以估计年龄依赖性变化。培养基中GIBS值与年龄相关（r = 0.84，p < 0.001）。P组的GIBS和中膜IMT分别从-17.8 +/- 2.4降至-20.1 +/- 3.7 dil和从1.7 +/- 0.3降至1.5 +/- 0.3 mm（p < 0.001），而D组的这些值分别从-18.3 +/- 2.0增加到16.7 +/- 2.1 dB和从1.6 +/- 0.3增加到1.7 +/- 0.2 mm（p < 0.001）。P组内膜IMT从3.7 ± 0.4 mm显著降低至3.3 ± 0.4 mm（p < 0.001）。11组内膜中的C-IBS从-10.2 +/- 2.2显著增加至-6.9 +/- 1.7 dB，这表明斑块稳定。匹伐他汀改善了中膜IMT测量的动脉粥样硬化和c-IBS值测量的硬化，并诱导了胸主动脉内膜斑块的稳定和消退。（电子邮件：masanori@ya2.so-net.ne.jp）（c）2009年世界医学和生物学超声联合会。
The effect of a strong, lipophilic statin (pitavastatin) on the thoracic aorta has not yet been elucidated. The purpose of the present study was to evaluate the effects of pitavastatin (P) therapy on plaque components and morphology in the thoracic aorta by transesophageal echocardiography (TEE) and clarify the impact of the therapy on media and intima in patients with hypercholesterolemia. Sixty-four media and 64 intima of the thoracic aorta were investigated in 32 patients with hypercholesterolemia. The corrected integrated backscatter (c-IRS) values in the thoracic aortic wall and intima-media thickness (IMT) at the same site were measured before and after P therapy or diet (D) for 7 mo. Moreover, c-IBS values in media were measured in 168 patients without hypercholesterolemia to estimate age-dependent changes. GIBS values in media were correlated with age (r = 0.84, p < 0.001). GIBS and IMT of media in the P group significantly decreased from - 17.8 +/- 2.4 to -20.1 +/- 3.7 dil and from 1.7 +/- 0.3 to 1.5 +/- 0.3 mm, respectively (p < 0.001), whereas those in the D group significantly increased from -18.3 +/- 2.0 to 16.7 +/- 2.1 dB and from 1.6 +/- 0.3 to 1.7 +/- 0.2 mm, respectively (p < 0.001). IMT in intima in the P group significantly decreased from 3.7 +/- 0.4 to 3.3 +/- 0.4 mm (p < 0.001). C-IBS in intima in the 11 group significantly increased from -10.2 +/- 2.2 to -6.9 +/- 1.7 dB, which indicated plaque stabilization. Pitavastatin improved the atherosis measured by IMT and sclerosis measured by c-IBS values in the media and induced stabilization and regression of plaques in the intima of the thoracic aorta. (E-mail: masanori@ya2.so-net.ne.jp) (c) 2009 World Federation for Ultrasound in Medicine & Biology.