Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis From 8,695 Old Adults
Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis From 8,695 Old Adults
复制标题
DOI：
10.1093/gerona/glac093
复制
发表时间：
2022-04-20
影响因子：
5.1
通讯作者：
Taki, Yasuyuki
中科院分区：
文献类型：
--
作者：
Liu, Yingxu;Zhang, Ye;Taki, Yasuyuki
利他的社会活动，如给予他人支持，已经显示出对痴呆风险和认知能力下降的保护作用。然而，其病理机制尚不清楚。在本研究中，我们研究了利他性社会活动与大脑区域灰质之间的关系。此外，为了探讨利他性社会活动中的心理相互作用，我们测试了抑郁症状对脑区域灰质的中介作用。我们对来自日本老龄化与痴呆前瞻性研究合作（JPSC-AD）队列的8695名老年人（72.9 +/- 6.1岁）进行了基于横断面体素的形态学（VBM）分析。我们用自我报告问卷测量利他社会活动，用老年抑郁量表(GDS)-短版测量抑郁症状。我们采用全脑VBM方法检测利他性社会活动的相关结构特性。然后，我们在调整可能的身体和社会生活方式协变量的同时，采用多元回归模型来检测抑郁症状对特定脑区域灰质体积的中介作用。我们发现，利他性社会活动与脑岛后部、中扣带回、海马、丘脑、颞上回、眶前回和枕中回的灰质体积增大有关。抑郁症状对利他性社会活动和海马体积的调节作用超过10%，对利他性社会活动和扣带回体积的调节作用超过20%。我们的研究结果表明，利他性的社会活动可能保留了对衰老和认知能力下降敏感的脑区域灰质。同时，这种关联可以通过对抑郁症状的间接影响来解释，这表明利他的社会活动可能减轻痴呆的神经病理。
Altruistic social activity, such as giving support to others, has shown protective benefits on dementia risk and cognitive decline. However, the pathological mechanism is unclear. In the present study, we investigated the association between altruistic social activity and brain regional gray matter. Furthermore, to explore the psychological interplay in altruistic social activity, we tested mediating effect of depressive symptoms on brain regional gray matter. We performed a cross-sectional voxel-based morphology (VBM) analysis including 8 695 old adults (72.9 +/- 6.1 years) from Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Cohort. We measured altruistic social activities by self-report questionnaires, depressive symptoms by Geriatric Depression Scale (GDS)-short version. We employed the whole-brain VBM method to detect relevant structural properties related to altruistic social activity. We then performed multiple regression models to detect the mediating effect of depressive symptoms on particular brain regional gray matter volume while adjusting possible physical and social lifestyle covariables. We found that altruistic social activity is associated with larger gray matter volume in posterior insula, middle cingulate gyrus, hippocampus, thalamus, superior temporal gyrus, anterior orbital gyrus, and middle occipital gyrus. Depressive symptoms mediated over 10% on altruistic social activity and hippocampus volume, over 20% on altruistic social activity and cingulate gyrus volume. Our results indicated that altruistic social activity might preserve brain regional gray matter which are sensitive to aging and cognitive decline. Meanwhile, this association may be explained by indirect effect on depressive symptoms, suggesting that altruistic social activity may mitigate the neuropathology of dementia.