Association between ankylosing spondylitis and chronic periodontitis: A population-based study
Association between ankylosing spondylitis and chronic periodontitis: A population-based study
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DOI：
10.1002/art.37746
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发表时间：
2013-01-01
影响因子：
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通讯作者：
Lin, Herng-Ching
中科院分区：
文献类型：
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作者：
Keller, Joseph J.;Kang, Jiunn-Horng;Lin, Herng-Ching
目的强直性脊柱炎（AS）是一种慢性炎症性风湿性疾病。有人认为，风湿性疾病可能有其他共同的慢性牙周炎的潜在因素。然而，很少有研究涉及AS和慢性牙周炎之间的可能联系。我们进行了目前的病例对照研究，以调查AS和慢性牙周炎之间的可能联系，使用人口为基础的数据集在台湾。方法本研究以台湾全民健康保险数据库中的行政索偿资料为研究对象。我们的研究包括6，821名AS患者和34，105名随机选择的对照组。进行条件Logistic回归分析，以计算优势比（OR）和95%置信区间（95%CI）的AS患者和匹配的对照组之间的既往慢性牙周炎。结果患者与对照组既往慢性牙周炎患病率差异有统计学意义（41.5%比25.9%; P < 0.001）。条件逻辑回归分析显示，患者比对照组更有可能先前被诊断患有慢性牙周炎（调整后OR 1.84 [95%CI 1.741.98]）。我们进一步发现，患者在索引日期前5年内接受牙龈切除术或牙周瓣手术（所有患者均有慢性牙周炎病史）的可能性仅为对照组的1.70倍（95%CI 1.561.89）。排除那些接受过牙龈切除术或牙周瓣手术的患者后，患者比对照组更有可能先前被诊断患有慢性牙周炎（调整后OR 2.04 [95%CI 1.932.15]）。结论本研究检测了AS与慢性牙周炎的既往诊断之间的关系。
Objective Ankylosing spondylitis (AS) is one type of chronic inflammatory rheumatic disease. It has been suggested that rheumatic diseases may have additional underlying factors in common with chronic periodontitis. However, few studies have addressed the possible link between AS and chronic periodontitis. We undertook the present casecontrol study to investigate the possible association between AS and chronic periodontitis using a population-based data set in Taiwan. Methods We conducted this study by using administrative claims data sourced from the Taiwan National Health Insurance program database. Our study included 6,821 AS patients and 34,105 randomly selected controls. Conditional logistic regression analyses were performed to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs) for prior chronic periodontitis among AS patients and matched controls. Results There was a significant difference in the prevalence of prior chronic periodontitis between patients and controls (41.5% versus 25.9%; P < 0.001). Conditional logistic regression analysis revealed that patients were more likely than controls to have been previously diagnosed as having chronic periodontitis (adjusted OR 1.84 [95% CI 1.741.98]). We further found that patients were only 1.70 (95% CI 1.561.89) times more likely than controls to have undergone a gingivectomy or periodontal flap operation (all patients had a history of chronic periodontitis) within the 5 years preceding the index date. After excluding those who had undergone either a gingivectomy or periodontal flap surgery, patients were even more likely than controls to have been previously diagnosed as having chronic periodontitis (adjusted OR 2.04 [95% CI 1.932.15]). Conclusion This study detected an association between AS and a prior diagnosis of chronic periodontitis.