Richness in Functional Connectivity Depends on the Neuronal Integrity within the Posterior Cingulate Cortex.
Richness in Functional Connectivity Depends on the Neuronal Integrity within the Posterior Cingulate Cortex.
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DOI：
10.3389/fnins.2017.00184
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发表时间：
2017
影响因子：
4.3
通讯作者：
Walter M
中科院分区：
文献类型：
--
作者：
Lord AR;Li M;Demenescu LR;van den Meer J;Borchardt V;Krause AL;Heinze HJ;Breakspear M;Walter M
大脑的连通性神经元--一个由紧密相连的成员组成的丰富的俱乐部--最初被证明存在于人类的结构网络中，但最近的证据表明存在一个功能上的对应物。这个富有的俱乐部通常包括来自多个规范网络的关键区域（或枢纽），从而降低了网络间通信的成本。后扣带皮层（PCC）是嵌入默认模式网络中的枢纽节点，有助于促进大脑网络之间的通信，是“富人俱乐部”的关键成员。在这里，我们评估了神经元的完整性和皮质厚度的代谢特征如何影响使用功能丰富的俱乐部系数（fRCC）测量的功能丰富的俱乐部的全球范围。对48名健康成年受试者在3 T下采集的静息态脑信号的功能连接进行Rich Club估计。磁共振波谱测量在同一会话中使用点分辨光谱序列。我们证实了功能性富人俱乐部与先前建立的结构性富人俱乐部的融合。PCC中的N-乙酰天冬氨酸（NAA）与年龄显著相关（p = 0.001），而富俱乐部系数显示年龄无影响（p = 0.106）。此外，我们发现PCC中fRCC和NAA浓度之间存在显著的二次关系（p = 0.009）。此外，皮质变薄的PCC与减少丰富的俱乐部系数后，占年龄和NAA。总之，我们发现fRCC与扣带皮层关键区域中的神经元完整性的标志物有关。此外，观察到在相同区域中的皮质变薄，这表明中枢区域中的皮质变薄和神经元完整性都影响全脑水平的功能整合。
The brain's connectivity skeleton—a rich club of strongly interconnected members—was initially shown to exist in human structural networks, but recent evidence suggests a functional counterpart. This rich club typically includes key regions (or hubs) from multiple canonical networks, reducing the cost of inter-network communication. The posterior cingulate cortex (PCC), a hub node embedded within the default mode network, is known to facilitate communication between brain networks and is a key member of the “rich club.” Here, we assessed how metabolic signatures of neuronal integrity and cortical thickness influence the global extent of a functional rich club as measured using the functional rich club coefficient (fRCC). Rich club estimation was performed on functional connectivity of resting state brain signals acquired at 3T in 48 healthy adult subjects. Magnetic resonance spectroscopy was measured in the same session using a point resolved spectroscopy sequence. We confirmed convergence of functional rich club with a previously established structural rich club. N-acetyl aspartate (NAA) in the PCC is significantly correlated with age (p = 0.001), while the rich club coefficient showed no effect of age (p = 0.106). In addition, we found a significant quadratic relationship between fRCC and NAA concentration in PCC (p = 0.009). Furthermore, cortical thinning in the PCC was correlated with a reduced rich club coefficient after accounting for age and NAA. In conclusion, we found that the fRCC is related to a marker of neuronal integrity in a key region of the cingulate cortex. Furthermore, cortical thinning in the same area was observed, suggesting that both cortical thinning and neuronal integrity in the hub regions influence functional integration of at a whole brain level.