Nevirapine inhibits the anti-HIV activity of CD8+ cells.
Nevirapine inhibits the anti-HIV activity of CD8+ cells.
复制标题
奈韦拉平抑制 CD8 细胞的抗 HIV 活性。
DOI：
10.1097/qai.0b013e318289822d
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Levy,JayA
中科院分区：
文献类型：
--
作者：
Liu,Lianxing;Wang,Lin;Huang,Liusheng;Siu,Vincent;Teque,Fernando;Aweeka,FrancescaT;Levy,JayA
Antiretroviral therapy (ART) significantly reduced the CD8+ cell noncytotoxic anti-HIV response in 12 HIV-1–infected subjects (P< 0.0001). In separate experiments, CD8+ cells from long-term survivors were cocultured with HIV-infected CD4+ cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8+ cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P< 0.05). The antiviral activity of CD8+ cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8+ cells and thus could influence the effectiveness of antiretroviral therapy.
