Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins
Differential heritability of eating attitudes and behaviors in prepubertal versus pubertal twins
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DOI：
10.1002/eat.10151
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发表时间：
2003-04-01
影响因子：
5.5
通讯作者：
Iacono, WG
中科院分区：
文献类型：
--
作者：
Klump, KL;McGue, M;Iacono, WG
目的：采用基于人群的双胞胎样本，研究青春期前、青春期和17岁双胞胎进食病理的不同遗传力。方法：研究对象包括来自明尼苏达双胞胎家庭研究的530名11岁儿童(452名青春期前双胞胎，78名青春期双胞胎)和602名17岁的女性双胞胎。用青春期发育量表评估青春期，用明尼苏达饮食失调问卷(M-EDI)的总分评估一般进食病理。结果：与青春期前11岁双胞胎相比，青春期11岁组的M-EDI总分组内相关性更接近于17岁双胞胎，这表明青春期和青春期队列中的遗传影响水平相似。模型拟合证实了这些印象，表明遗传因素在11岁青春期前双胞胎中解释了0%的变异，但在11岁青春期和17岁双胞胎中解释了54%的变异。讨论：研究结果表明，基因对饮食病理的部分影响可能在青春期被激活。(C)2003年，由威利期刊公司出版。
Objective: Differential heritability of eating pathology in prepubertal, pubertal, and 17-year-old twins was examined using a population-based twin sample. Method: Participants included 530 11-year-old (452 prepubertal, 78 pubertal twins) and 602 17-year-old female twins from the Minnesota Twin Family Study. Puberty was assessed with the Pubertal Development Scale, and general eating pathology was assessed with the total score from the Minnesota Eating Disorders Inventory (M-EDI). Results: M-EDI total score intraclass correlations for the pubertal 11-year-old group were more similar to the 17-year-old twins' than the prepubertal 11-year-old twins, suggesting similar levels of genetic influence in the pubertal and older adolescent cohort. Model-fitting corroborated these impressions, indicating that genetic factors accounted for 0% of the variance in 11-year-old prepubertal twins but 54% of the variance in 11-year-old pubertal and 17-year-old twins. Discussion: Findings suggest that a portion of the genetic influence on eating pathology may become activated during puberty. (C) 2003 by Wiley Periodicals, Inc.