Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women
Incubation period and risk factors support sexual transmission of bacterial vaginosis in women who have sex with women
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DOI：
10.1136/sextrans-2018-053824
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发表时间：
2019-11-01
影响因子：
3.6
通讯作者：
Schwebke, Jane R.
中科院分区：
文献类型：
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作者：
Muzny, Christina Ann;Lensing, Shelly Y.;Schwebke, Jane R.
目的细菌性阴道病(BV)的流行病学特征有利于BV相关细菌的性传播。我们在一项对与女性发生性行为的妇女(WSW)的前瞻性研究中检查了BV(IBV)事件的潜伏期和危险因素。方法采用每日采集的阴道拭子，对阴道微生物区系正常(无Amsel标准，Nugent评分0~3分)的WSW进行90天的随访，或直至IBV(Nugent评分7~10分，至少连续2~3天)。完成了有关性行为和月经的日常日记。估计到达IBV的时间。考虑到不同的随访时间和年龄，性行为比率(每100个人日(PD))根据IBV状况进行了比较。并对月经与IBV的关系进行了探讨。结果36例WSW中，平均年龄30岁(SD8)，其中92%为非裔美国人。30天和60天发生IBV的概率分别为20%(SD 7%)和36%(SD 8%)，14例(39%)在90天发生IBV。有传染性支气管炎的女性与无传染性支气管炎的女性相比，在感染IBV前发生性行为的相对比率高40%(20.4vs14.6/100pd；p=0.010)，与女性发生性行为的比例高38%(14.3vs10.3/100pd；p=0.038)，指阴性行为增加57%(14.3vs9.1‰；p=0.005)，指肛交增加5.6倍(2.9vs0.5/100pd；p=0.005)。
Objective The epidemiology of bacterial vaginosis (BV) favours sexual transmission of BV-associated bacteria. We examined incubation period and risk factors for incident BV (iBV) in a prospective study of women who have sex with women (WSW). Methods Using daily self-collected vaginal swabs, WSW with normal vaginal microbiota (no Amsel criteria and a Nugent score of 0-3) were followed for 90 days or until iBV (Nugent score 7-10 on at least 2-3 consecutive days). Daily diaries of sexual activity and menses were completed. Time to iBV was estimated. Accounting for differing lengths of follow-up and age, rates of sexual activities (per 100 person-days (pd)) were compared according to iBV status. The relationship between menses and iBV was also investigated. Results Of the 36 WSW, the mean age was 30 years (SD 8) and 92% were African American. The probability of iBV at 30 and 60 days was 20% (SD 7%) and 36% (SD 8%), respectively; 14 (39%) developed iBV by 90 days. In WSW with iBV versus those without iBV, the relative rate of any sexual activity prior to iBV was 40% higher (20.4 vs 14.6 per 100 pd; p=0.010), sex with a woman was 38% higher (14.3 vs 10.3 per 100 pd; p=0.038), digital-vaginal sex was 57% higher (14.3 vs 9.1 per 100 pd; p=0.005) and digital-anal sex was 5.6 times higher (2.9 vs 0.5 per 100 pd; p